IMPROVED ISOLATED HEART CONTRACTILITY AND MITOCHONDRIAL OXIDATION AFTER CHRONIC TREATMENT WITH PANAX-GINSENG IN RATS
IMPROVED ISOLATED HEART CONTRACTILITY AND MITOCHONDRIAL OXIDATION AFTER CHRONIC TREATMENT WITH PANAX-GINSENG IN RATS
复制标题
DOI：
10.1142/s0192415x94000334
复制
发表时间：
1994-01-01
影响因子：
5.7
通讯作者：
TOH, HT
中科院分区：
文献类型：
--
作者：
TOH, HT
新鲜分离的人参处理大鼠心脏线粒体在adp诱导下呼吸频率更高，状态3呼吸频率更高，呼吸指数更高。这些线粒体不太容易受到实验诱导的功能损伤。用人参提取物孵育的对照心脏线粒体也表明，人参可以防止线粒体与nadd连接的底物孵育引起的恶化。对离体心脏、灌注心脏和电节律心脏的收缩力的比较表明，在整个实验过程中，人参处理的大鼠心脏收缩力的恶化始终较小。上述结果表明，人参具有延缓实验性心肌线粒体损伤和肌肉收缩恶化的作用。
Heart mitochondria freshly isolated from ginseng treated rats respired higher at ADP-induced, state 3 respiratory rates and with greater respiratory indices. These mitochondria were less susceptible to experimentally-induced functional impairment. Control heart mitochondria incubated with ginseng extract also showed that ginseng prevented mitochondria from incubation induced deterioration with NAD-linked substrates. Comparison of force of contraction of isolated, perfused and electrically paced hearts showed that deterioration of the force of heart contraction was consistently smaller throughout the experiment in hearts from ginseng treated rats. These results indicated that Panax ginseng was able to delay experimently induced heart mitochondrial impairment and muscle contraction deterioration.