Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY)
Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY)
复制标题
DOI：
10.3109/10641969609081765
复制
发表时间：
1996-02-01
影响因子：
12.3
通讯作者：
Berecek, KH
中科院分区：
文献类型：
--
作者：
Zhang, L;Edwards, DG;Berecek, KH
本研究的目的是评价早期给予和撤除血管紧张素转换酶抑制剂卡托普利（CAP）对SHR、WKY大鼠（SHR、WKY、SHRCAP、WKYCAP）、对照组、CAP处理组和不给予CAP的SHR（OFFCAP）及其子代（第二代）血浆ACE活性、AVP水平和平均动脉压（MAP）的影响。SHRCAP组血浆ACE活性（54.8 ± 2.1 mU/ml/min）显著高于SHR组（25.96 ± 0.34 mU/ml/min）及其后代组（OFFCAP组，26.32 ± 2.71 mU/ml/min和第2代，17.62 ± 2.47 mU/ml/min，P
The purpose of this study was to evaluate the effects of early administration and removal of the ACE inhibitor, captopril (CAP) on the plasma ACE activity, AVP levels, and mean arterial pressure (MAP)in groups of rats, control and CAP treated SHR and WKY (SHR, WKY SHRCAP, WKYCAP, respectively and in SHR taken off CAP (OFFCAP) and their progeny (2nd generation, 2ndG). Plasma ACE activity in SHRCAP (54.8+/-2.1 mU/ml/min) was significantly greater than in SHR (25.96+/-0.34 mU/ml/min) and their offspring (OFFCAP, 26.32+/-2.71 and 2 nd G, 17.62+/-2.47 mU/ml/min, P