Fast-slow asymptotics for a Markov chain model of fast sodium current.
Fast-slow asymptotics for a Markov chain model of fast sodium current.
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DOI：
10.1063/1.5003013
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发表时间：
2017-03
期刊：
影响因子：
2.9
通讯作者：
T. Stary;V. Biktashev
中科院分区：
文献类型：
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作者：
T. Stary;V. Biktashev
我们探索了使用快慢渐进来消除心脏兴奋性离子通道的离散状态、连续时间确定性马尔可夫链模型的计算刚性的可行性。我们关注快速钠电流的马尔可夫链模型，并研究其关于以不同方式识别的小参数的渐近行为。
We explore the feasibility of using fast-slow asymptotics to eliminate the computational stiffness of discrete-state, continuous-time deterministic Markov chain models of ionic channels underlying cardiac excitability. We focus on a Markov chain model of fast sodium current, and investigate its asymptotic behaviour with respect to small parameters identified in different ways.