Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) exposure among native American men from contaminated Great Lakes fish and wildlife
Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) exposure among native American men from contaminated Great Lakes fish and wildlife
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DOI：
10.1177/074823379601200308
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发表时间：
1996-05-01
影响因子：
1.9
通讯作者：
Tarbell, A
中科院分区：
文献类型：
--
作者：
Fitzgerald, EF;Brix, KA;Tarbell, A
纽约州卫生部正在对居住在纽约、安大略和魁北克圣劳伦斯河沿着Akwesasne保护区的莫霍克族男子、妇女和婴儿进行调查。与Akwesasne保护区接壤的三个大型工业设施严重污染了邻近的圣劳伦斯河的土壤、沉积物和鱼类，其中含有多氯联苯。主要研究目标是调查当地捕获的鱼类消费，住宅暴露，体内多氯联苯的负担，和肝酶诱导之间的关联。多氯联苯、多氯二苯并呋喃、多氯二苯并二恶英、多环芳烃、二氯二苯二氯乙烯（DDE）和其他化学品的污染已在当地捕获的鱼、鸭和其他野生动物中记录在案。鱼类和野生动物的污染是莫霍克人的一个主要关切，因为他们的传统和文化强调人与环境的相互依存关系，而且许多居民以前严重依赖当地的鱼类和水禽作为食物。从1986年至1992年，这项研究的重点是哺乳妇女和婴儿。本项目的主要目的是确定饮食、居住和职业暴露于多氯联苯和DDE与莫霍克男性个体身体负担之间是否存在关联，特别是我们其他研究中女性的丈夫、伴侣、父亲、兄弟或其他男性亲属。在其他吃鱼的人群中，成年男性往往表现出比妇女和儿童更高的PCB和DDE身体负担。根据报告的当地捕获的鱼类和野生动物的消费量以及居住历史得出的接触估计数将与血清中发现的多氯联苯同系物的具体模式相关联，从而确定两种潜在接触源与身体负担之间的直接关系。将通过咖啡因呼吸试验（CBT）检查肝功能，这是一种敏感的、非侵入性的酶诱导评估方法，是实验室动物对多氯联苯最早可检测到的生物反应之一。该试验作为一种在明显临床症状发作前检测细微亚临床效应的方法似乎很有前途。该项目是第一个探索饮食和其他接触、身体负担以及由于特定多氯联苯同系物对来自同一来源人口的男性和女性造成的潜在不良健康影响的项目。
The New York State Department of Health is performing an investigation of Mohawk men, women, and infants who live at the Akwesasne Reserve along the St. Lawrence River in New York, Ontario, and Quebec. Three large industrial facilities bordering the Akwesasne Reserve have seriously contaminated the soil and the sediments and fish of the adjacent St. Lawrence River with polychlorinated biphenyls (PCBs). The main study goals are to investigate the associations among the consumption of locally caught fish, residential exposure, body burdens of PCBs, and liver enzyme induction. Contamination with PCBs, polychlorinated dibenzofurans, polychlorinated dibenzodioxins, polyaromatic hydrocarbons, dichlorodiphenyl dichloroethylene (DDE) and other chemicals has been documented in locally caught fish, ducks, and other wildlife. The contamination of fish and wildlife is a major concern of the Mohawk people, since their tradition and culture emphasize the interdependence of man and his environment and because many residents formerly depended heavily on local fish and waterfowl for food. The focus of this research from 1986-1992 was on nursing women and infants. The major purpose of the current project is to determine if there are associations between dietary, residential, and occupational exposures to PCBs and DDE and individual body burdens in Mohawk men, specifically the husbands, partners, fathers, brothers, or other male relatives of the women in our other studies. In other fish-eating populations, adult men have tended to demonstrate higher PCB and DDE body burdens than women and children. Exposure estimates based on the reported consumption of locally caught fish and wildlife and residential histories will be correlated with the specific pattern of PCB congeners found in serum, thereby establishing a direct relationship between two potential sources of exposure and body burdens. Liver function will be examined through the caffeine breath test (CBT), a sensitive, noninvasive method of assessment of enzyme induction, one of the earliest detectable biological responses to PCBs in laboratory animals. This test appears promising as a method to detect subtle subclinical effects before the onset of overt clinical symptoms. The project is among the first to explore differences in dietary and other exposures, body burdens, and potential adverse health effects due to specific PCB congeners in men and women from the same source population.