Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy

Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy
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使用癌症小组测试表征并采用含利妥昔单抗的化疗治疗的侵袭性脾边缘区淋巴瘤变体

DOI:
10.1097/md.0000000000021938
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发表时间:
2020
期刊:
影响因子:
1.6
通讯作者:
Matsuno Yoshihiro
Matsuno Yoshihiro
中科院分区:
医学4区
文献类型:
--
作者:
Ishiguro Kazuya;Sasaki Yasushi;Takagi Yoshitake;Niinuma Takeshi;Suzuki Hiromu;Tokino Takashi;Hayashi Toshiaki;Takahashi Tohru;Igarashi Tetsuyuki;Matsuno Yoshihiro

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干预措施:患者接受了含利妥昔单抗的治疗方案和利妥昔单抗维持治疗。结果:患者继续表现出完全缓解。教训:这是一例AV-SMZL,其中癌症面板测试成功检测到可能与其发病机制相关的遗传变异。这些发现表明,遗传分析对于诊断AV-SMZL以及确定治疗策略非常有用。
Interventions:The patient was administered a rituximab-containing regimen and rituximab-maintenance therapy.Outcomes:The patient continues to exhibit a complete response.Lessons:This is a case of AV-SMZL in which a cancer panel test successfully detected genetic alterations that are potentially associated with its pathogenesis. These findings suggest that genetic analysis is useful for making diagnoses as well as for determining treatment strategies in AV-SMZL.
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