Interleukin-6 levels in colorectal cancer tissues
Interleukin-6 levels in colorectal cancer tissues
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DOI：
10.1007/s002689900489
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发表时间：
1998-08-01
影响因子：
2.6
通讯作者：
Takao, T
中科院分区：
文献类型：
--
作者：
Komoda, H;Tanaka, Y;Takao, T
检测32例大肠癌患者癌组织中白细胞介素-6（IL-6）水平，并与临床病理结果进行相关性分析。癌组织中的IL-6水平为81.1 +/-：118.0 pg/mg蛋白，显著高于正常结直肠组织中的11.2 +/- 20.8 pg/mg蛋白（p = 0.028）。癌组织中IL-6水平与静脉浸润、淋巴浸润、淋巴结转移或肝转移的发生率无关。癌组织中IL-6水平随癌组织浸润深度的增加而降低。我们的研究结果表明，IL-6可能在人类结直肠癌的生长中发挥作用。
Interleukin-6 (IL-6) levels in cancer tissues of 32 patients with colorectal cancer were measured and analyzed in relation to the clinicopathologic findings. The IL-6 level in cancer tissues was 81.1 +/-: 118.0 pg/mg protein, which was significantly higher than the 11.2 +/- 20.8 pg/mg protein in normal colorectal tissues (p = 0.028). IL-6 levels in cancer tissues showed no correlation with the incidence of venous invasion, lymphatic invasion, lymph node involvement, or liver metastasis. The IL-6 level in cancer tissue tended to decrease as the cancer penetration extended. Our results suggest that IL-6 may play a role in human colorectal cancer growth.