The outcome and burden of Chinese patients with neurodegenerative diseases: A 10-year clinical feature study
The outcome and burden of Chinese patients with neurodegenerative diseases: A 10-year clinical feature study
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中国神经退行性疾病患者的结局和负担：10年临床特征研究
DOI：
10.1111/ijcp.13534
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发表时间：
2020-06-09
影响因子：
2.6
通讯作者：
Xu，Ping-Yi
中科院分区：
文献类型：
--
作者：
Li，Gui-Hua;Li，Peng;Xu，Ping-Yi
背景随着中国人口持续老龄化，神经退行性疾病（NDD）的发病率急剧上升，给家庭和社会带来沉重的医疗和经济负担。目的本研究的目的是评估中国南方一家医院10年的NDD，并探讨人口统计学、结果、住院时间（LOS）和费用的趋势。方法收集2010年1月至2019年12月患者的回顾性病历，包括7231名神经退行性疾病患者。患有NDD的患者（作为病例组）和9663名没有任何NDD的患者（作为对照组）。提取并分析社会人口统计数据、入院来源、入院原因、结果、LOS和费用等信息。结果NDDs患者的平均住院年龄超过65岁（高峰年龄70-89岁）。与对照组相比，病例组LOS较长，费用较高，2010年至2019年NDD患者数量逐年增加，LOS缩短，费用增加。临床特征影响 LOS 和成本。以感染、血压异常、水电解质平衡失衡为主要入院原因的患者减少；但心脏病、脑血管意外、精神疾病明显增多，骨折/外伤总体变化趋势保持稳定。出院到家庭护理的比率和死亡率下降； 10 年来，出院到其他医疗或社区设施的人数有所增加。结论 大多数 NDD 患者年龄偏大。从2010年到2019年的10年间，NDD患者数量逐年增加，LOS呈缩短趋势，费用逐渐增加。入院主要原因及住院结局呈现不同趋势。
BackgroundAs the Chinese population continues to age, the incidence of neurodegenerative diseases (NDDs) has increased dramatically, which results in heavy medical and economic burden for families and society.ObjectiveThe objective of this study was to evaluate NDDs in a southern Chinese hospital over a 10‐year period and examine trends in demographics, outcome, length of stay (LOS) and cost.MethodsRetrospective medical records of patients from January 2010 to December 2019 were collected, including 7231 patients with NDDs (as case group) and 9663 patients without any NDDs (as control group). The information of social demographic data, admission source, reasons for admission, outcomes, LOS, and cost were extracted and analysed.ResultThe average hospitalisation age of the patients with NDDs is over 65 years (peak age 70‐89 years). Compared with the control group, the case group had a longer LOS and a higher cost and the numbers of patients with NDDs increased yearly from 2010 to 2019. The LOS shortened while the cost increased. Clinical features affected LOS and cost. Patients suffering from infection, abnormal blood pressure and the imbalance of water‐electrolyte homoeostasis as main reasons for admission were decreased; however, heart disease, cerebrovascular accident and mental diseases were significantly increased, the overall change trend of fracture/trauma remained stable. The rate of discharge to home care and mortality declined; discharge to other medical or community facilities increased over 10 years.ConclusionThe majority of NDDs patients tended to be older. During the last 10 years from 2010 to 2019, the numbers of NDDs patients increased yearly, the trend of LOS became shortening and the cost gradually increasing. The main reasons of admission and outcomes of hospital showed different trends.