A historical perspective on the discovery of statins.
A historical perspective on the discovery of statins.
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DOI：
10.2183/pjab.86.484
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Endo A
中科院分区：
文献类型：
--
作者：
Endo A
胆固醇对于所有人体器官的功能至关重要，但它仍然是冠心病的原因。经过近一个世纪的研究，科学家们已经找到了几条证据，证实血液胆固醇、动脉粥样硬化和冠心病之间存在因果关系。基于这些知识，科学家和制药行业成功开发出了一类非常有效的药物——他汀类药物——可以降低血液中的胆固醇水平并减少心脏病发作的频率。
Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease. Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs—the statins—that lower cholesterol levels in blood and reduce the frequency of heart attacks.