Sustained microtubule treadmilling in Arabidopsis cortical arrays
Sustained microtubule treadmilling in Arabidopsis cortical arrays
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DOI：
10.1126/science.1083529
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发表时间：
2003-06-13
期刊：
影响因子：
56.9
通讯作者：
Ehrhardt, DW
中科院分区：
文献类型：
--
作者：
Shaw, SL;Kamyar, R;Ehrhardt, DW
植物细胞在细胞皮层形成高度结构化的微管阵列，没有中央组织中心来固定微管末端。拟南芥植物个体微管的体内成像显示，新的微管在细胞皮层启动，并在两端表现出动态。一端偏向聚合的动态不稳定性和另一端缓慢的解聚导致微管通过混合跑步机制在细胞皮层上持续迁移。这种运动引起广泛的微管重新定位，并通过微管重新定向和捆绑导致阵列组织的变化。
Plant cells create highly structured microtubule arrays at the cell cortex without a central organizing center to anchor the microtubule ends. In vivo imaging of individual microtubules in Arabidopsis plants revealed that new microtubules are initiated at the cell cortex and exhibit dynamics at both ends. Polymerization-biased dynamic instability at one end and slow depolymerization at the other end result in sustained microtubule migration across the cell cortex by a hybrid treadmilling mechanism. This motility causes widespread microtubule repositioning and contributes to changes in array organization through microtubule reorientation and bundling.