Individual differences in spatial pattern separation performance associated with healthy aging in humans
Individual differences in spatial pattern separation performance associated with healthy aging in humans
复制标题
DOI：
10.1101/lm.1768110
复制
发表时间：
2010-06-01
影响因子：
2
通讯作者：
Stark, Craig E. L.
中科院分区：
文献类型：
--
作者：
Stark, Shauna M.;Yassa, Michael A.;Stark, Craig E. L.
啮齿类动物的研究表明，“模式分离”，即区分相似经历的能力，在一部分老年大鼠中减弱。我们使用一项旨在评估空间模式分离行为的任务（在测试时确定研究期间显示的图片对是否处于相同的空间位置）将这些发现扩展到人类。使用标准化测试的单词回忆分为健康的老年人受损和未受损组相对于年轻的性能，我们表明，老年受损的成年人偏离模式分离和模式完成，与啮齿动物的研究一致。
Rodent studies have suggested that "pattern separation," the ability to distinguish among similar experiences, is diminished in a subset of aged rats. We extended these findings to the human using a task designed to assess spatial pattern separation behavior (determining at time of test whether pairs of pictures shown during the study were in the same spatial locations). Using a standardized test of word recall to divide healthy aged adults into impaired and unimpaired groups relative to young performance, we demonstrate that aged impaired adults are biased away from pattern separation and toward pattern completion, consistent with the rodent studies.