Inhibition and activation of cholesteryl ester transfer and its significance in plasma cholesterol metabolism.
Inhibition and activation of cholesteryl ester transfer and its significance in plasma cholesterol metabolism.
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胆固醇酯转移的抑制和激活及其在血浆胆固醇代谢中的意义。
DOI：
10.1007/978-1-4684-1262-8_18
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发表时间：
1986
影响因子：
--
通讯作者：
Fielding,CJ
中科院分区：
文献类型：
--
作者：
Fielding,CJ
胆固醇酯在血浆中的转移可以被定义为在脂蛋白颗粒之间催化形成的胆固醇酯的移动。在哺乳动物血浆中，这种活性存在于一类或多类转运蛋白中，这些转运蛋白对疏水性脂类如胆固醇、视黄醇基酯和甘油三酯表现出专一性。1-3已有研究表明，催化的机制在于这种转运蛋白能够增加这些脂类在血浆中的溶解度，从而增加脂类表面之间的扩散速率。4或者，转运蛋白可以促进供体和受体脂蛋白颗粒之间的复合体的形成。5使用标记的胆固醇酯和三酸甘油酯的研究表明，这种转移是双向的。6然而，这些脂类在不同脂蛋白中的有效浓度通常不同；因此，正向转移和反向转移的速率将不相同，并将导致胆固醇酯的净转移。
Cholesteryl ester transfer in plasma can be defined as the catalyzed movement of preformed cholesteryl ester between lipoprotein particles. In mammalian plasma, this activity resides in one or more of a class of transfer proteins which show specificity for hydrophobic lipids such as cholesteryl and retinyl esters and triglycerides.1–3It has been suggested that the mechanism of catalysis is in the ability of such transfer proteins to increase the solubility of these lipids in plasma and in that way increase diffusion rates between lipid surfaces.4Alternatively, the transfer protein may facilitate complex formation between donor and acceptor lipoprotein particles.5Studies using labeled cholesteryl esters and triglycerides indicate that transfer is bidirectional.6However, the effective concentration of these lipids in different lipoproteins in usually not the same; as a result, the forward and back rates of transfer will not be identical and a net transfer of cholesteryl ester will result.