Intralipid emulsion treatment as an antidote in lipophilic drug intoxications
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications
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DOI：
10.1016/j.ajem.2014.05.019
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发表时间：
2014-09-01
影响因子：
3.6
通讯作者：
Guneysel, Ozlem
中科院分区：
文献类型：
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作者：
Cevik, Sebnem Eren;Tasyurek, Tanju;Guneysel, Ozlem
静脉注射脂肪乳剂（ILE）是亲脂性药物中毒的一种救命治疗方法。ILE不仅作为局部麻醉剂毒性的解毒剂具有明显的功效，而且在亲脂性药物中毒中也有效。我们的病例系列涉及10例患者摄入不同类型的亲脂性药物。根据药物类型，静脉脂肪乳剂治疗改善了格拉斯哥昏迷评分或血压和脉率或两者。在2例患者中观察到并发症（轻微病变胰腺炎和可能的ILE治疗相关的肺部脂肪浸润）。在我们的病例系列中，ILE用于不同的亲脂性药物中毒，以改善心血管和神经系统症状。根据结果，发现ILE治疗是亲脂性药物中毒的救生剂，并且它可以用于具有心脏和/或神经症状但没有特定药物摄入史的无意识患者。(C)2014爱思唯尔公司All rights reserved.
Intravenous lipid emulsion (ILE) is a lifesaving treatment of lipophilic drug intoxications. Not only does ILE have demonstrable efficacy as an antidote to local anesthetic toxicity, it is also effective in lipophilic drug intoxications. Our case series involved 10 patients with ingestion of different types of lipophilic drugs. Intravenous lipid emulsion treatment improved Glasgow Coma Scale or blood pressure and pulse rate or both according to the drug type. Complications were observed in 2 patients (minimal change pancreatitis and probable ILE treatment-related fat infiltration in lungs).In our case series, ILE was used for different lipophilic drug intoxications to improve cardiovascular and neurologic symptoms. According to the results, it was found that ILE treatment is a lifesaving agent in lipophilic drug intoxications and it can be used in unconscious patients who have cardiac and/or neurologic symptoms but no history of a specific drug ingestion. (C) 2014 Elsevier Inc. All rights reserved.