The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese
The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese
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DOI：
10.1196/annals.1375.007
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Ogihara, Toshio
中科院分区：
文献类型：
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作者：
Asano, Katsuaki;Ikegami, Hiroshi;Ogihara, Toshio
1型糖尿病在人类和NOD小鼠中都处于多基因控制之下。最近，在NOD小鼠身上证实了IL-21在1型糖尿病发病机制中的可能作用。此外，小鼠IL-21基因被映射到Idd3区间，使人IL-21基因(IL21)成为易感性的功能和位置候选基因。因此，我们筛选了IL21的序列变异，并研究了其与1型糖尿病的关系。初步数据显示，IL21基因多态性与该病没有关联，这表明IL21基因在日本人患1型糖尿病的易感性中起的作用很小。
Type 1 diabetes is under polygenic control both in humans and the NOD mouse. Recently a possible role of IL-21 in the pathogenesis of type 1 diabetes was demonstrated in the NOD mouse. Furthermore, the murine IL-21 gene is mapped to the Idd3 interval, making the human IL-21 gene (IL21) a functional as well as positional candidate for susceptibility. We therefore screened sequence variants of IL21 and studied the association with type 1 diabetes. Preliminary data showed no association of IL21 polymorphisms with the disease, suggesting that IL21 plays little role in susceptibility to type 1 diabetes in Japanese.