Lysosomal Biology in Cancer.
Lysosomal Biology in Cancer.
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DOI：
10.1007/978-1-4939-6934-0_19
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Amaravadi RK
中科院分区：
文献类型：
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作者：
Fennelly C;Amaravadi RK
细胞依靠溶酶体来螯合和降解大分子，以维持代谢稳态。这些膜封闭的细胞器可以通过内吞作用、吞噬作用和自噬作用接收细胞内和细胞外货物。溶酶体建立酸性环境来激活酶，这些酶能够分解通过这些不同途径吞噬的生物分子。研究溶酶体的方法的最新进展已经允许发现溶酶体在包括癌症在内的各种疾病中的扩展作用，使其成为治疗干预的有吸引力和可靶向的节点。本文综述了癌症背景下溶酶体生物学的关键方面，以及如何利用这些特性开发新的治疗策略。这将提供一个背景框架，如何在方法学的进步可以应用于未来的翻译研究。
Cells depend on the lysosome for sequestration and degradation of macromolecules in order to maintain metabolic homeostasis. These membrane-enclosed organelles can receive intracellular and extracellular cargo through endocytosis, phagocytosis, and autophagy. Lysosomes establish acidic environments to activate enzymes that are able to break down biomolecules engulfed through these various pathways. Recent advances in methods to study the lysosome have allowed the discovery of extended roles for the lysosome in various diseases, including cancer, making it an attractive and targetable node for therapeutic intervention. This review focuses on key aspects of lysosomal biology in the context of cancer and how these properties can be exploited for the development of new therapeutic strategies. This will provide a contextual framework for how advances in methodology could be applied in future translational research.