COMPARATIVE VIRULENCE AND IMMUNOGENICITY OF THE TOWNE STRAIN AND A NONATTENUATED STRAIN OF CYTOMEGALOVIRUS
COMPARATIVE VIRULENCE AND IMMUNOGENICITY OF THE TOWNE STRAIN AND A NONATTENUATED STRAIN OF CYTOMEGALOVIRUS
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DOI：
10.7326/0003-4819-101-4-478
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发表时间：
1984-01-01
影响因子：
39.2
通讯作者：
HILLEMAN, MR
中科院分区：
文献类型：
--
作者：
QUINNAN, GV;DELERY, M;HILLEMAN, MR
在健康成年男性受试者中比较了 Towne 株巨细胞病毒和低传代株 Toledo-1 的毒力和免疫原性，以确定 Towne 株是否适合接种疫苗。接受 Toledo-1 毒株的五名血清反应呈阳性的受试者出现了感染，其严重程度从实验室异常到轻度单核细胞增多症综合征（平均潜伏期，4.7 周）。接受 Towne 毒株的 4 名血清阴性受试者均未出现全身感染，但均在注射部位出现迟发性局部反应。所有受试者都出现了针对巨细胞病毒的细胞毒性淋巴细胞反应，通常是 HLA 限制性的，但在 Toledo-1 受体中，这些反应的幅度更大，持续时间更长。后者还出现自然杀伤细胞和干扰素反应、非典型淋巴细胞增多、辅助细胞/抑制细胞比例倒置以及对 T 细胞有丝分裂原的反应减弱，而这些在 Towne 品系受体中均未发生。结果进一步证实了Towne株巨细胞病毒的无毒力和免疫原性。
The Towne strain cytomegalovirus and a low-passage strain, Toledo-1, were compared for virulence and immunogenicity in healthy adult male subjects to determine the suitability of the Towne strain for vaccination. Five seropositive subjects who received the Toledo-1 strain developed infections ranging in severity from laboratory abnormalities to mild mononucleosis syndromes (mean incubation, 4.7 wk). None of the 4 seronegative subjects receiving the Towne strain developed systemic infection, but all developed delayed local reactions at the injection sites. All subjects developed cytotoxic lymphocyte responses specific to cytomegalovirus, usually HLA-restricted, but these were of greater magnitude and duration in the Toledo-1 recipients. The latter also developed natural killer cell and interferon responses, atypical lymphocytosis, inversion of helper/suppressor cell ratios, and depressed responses to T-cell mitogens, none of which occurred in Towne strain recipients. The results further substantiate the avirulence and immunogenicity of the Towne strain cytomegalovirus.