ENDOTHELIAL-CELL ADHESIVE RECEPTORS
ENDOTHELIAL-CELL ADHESIVE RECEPTORS
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DOI：
10.1097/00005344-199321001-00004
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发表时间：
1993-01-01
影响因子：
3
通讯作者：
DEJANA, E
中科院分区：
文献类型：
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作者：
DEJANA, E
内皮细胞表达多种粘附受体，调节其与细胞外基质的粘附和细胞-细胞连接的组织。到目前为止，大多数内皮细胞基质蛋白受体都属于整合素超家族。内皮细胞和许多其他类型的细胞一样，在其表面有许多不同的整合素。这表明与基质蛋白的相互作用是一个复杂的现象，需要多种（可能冗余的）识别机制。我们对内皮细胞-细胞连接的结构只有有限的了解。整合素也被发现存在于这些结构中。这表明它们也可以在这种同型型细胞相互作用中发挥作用。然而，在内皮细胞间的接触中发现了与整合素在结构和功能上不同的其他分子。这些蛋白质的相互作用仍有待完全确定。
Endothelial cells express a variety of adhesive receptors that regulate their adhesion to extracellular matrix and organization of cell-cell junctions. Most of the endothelial cell receptors for matrix proteins, characterized so far, belong to the integrin superfamily. Endothelial cells, as many other cell types, have many different integrins on their surface. This indicates that the interaction with matrix proteins is a complex phenomenon that requires multiple (and possibly redundant) recognition mechanisms. We have only a limited knowledge of the structures involved in endothelial cell-cell junctions. Integrins have been found to be localized in these structures too. This suggests that they can play a role also in this homotypic type of cell interaction. Other molecules, however, that are structurally and functionally distinct from integrins have been found in endothelial cell-to-cell contacts. The reciprocal role of these proteins remains to be fully defined.