Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task
Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task
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DOI：
10.1002/hbm.10075
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发表时间：
2003-01-01
影响因子：
4.8
通讯作者：
Buonocore, MH
中科院分区：
文献类型：
--
作者：
Maddock, RJ;Garrett, AS;Buonocore, MH
功能成像研究一致发现，情绪刺激会激活后扣带皮层，这一区域似乎具有与记忆相关的功能。然而，先前的成像研究没有控制非情绪刺激特征，这些特征可能通过参与与情绪无关的记忆过程来激活该区域。本研究探讨了当这些潜在的混杂因素被控制时，情绪词是否激活了后扣带皮层。64个愉快的和64个不愉快的词与已知影响记忆的非情感特征的中性词相匹配。八名受试者在评估这些单词的效价时接受了块设计的功能磁共振成像扫描。后扣带皮层显着激活双边在不愉快和愉快相比，中性词。无论是令人不愉快的还是令人愉快的词语，最强的激活峰都出现在左侧膝下扣带皮质。前内侧眼眶和左下和中额叶皮质也被愉快和不愉快的话激活。右侧杏仁核和听觉皮层只被不愉快的词激活，而左侧额叶只被愉快的词激活。结果表明，情绪刺激激活后扣带皮层不能归因于非情绪刺激特征的记忆增强效应。这些发现与该区域可能介导情绪和记忆相关过程的相互作用的建议是一致的。研究结果也扩展了先前的发现，即评估情绪词汇始终激活了膝下扣带皮层，并提出了一种探测情绪障碍患者这一区域的方法。(C)2002 Wiley-Liss，Inc.
Functional imaging studies consistently find that emotional stimuli activate the posterior cingulate cortex a region that appears to have memory-related functions. However, prior imaging studies have not controlled for non-emotional stimulus features that might activate this region by engaging memory processes unrelated to emotion. This study examined whether emotional words activated the posterior cingulate cortex when these potentially confounding factors were controlled. Sixty-four pleasant and 64 unpleasant words were matched with neutral words on non-emotional features known to influence memory. Eight subjects underwent block-designed functional magnetic resonance imaging scans while evaluating the valence of these words. The posterior cingulate cortex was significantly activated bilaterally during both unpleasant and pleasant compared to neutral words. The strongest activation peak with both unpleasant and pleasant words was observed in the left subgenual cingulate cortex. Anteromedial orbital and left inferior and middle frontal cortices were also activated by both pleasant and unpleasant words. Right amygdala and auditory cortex were activated only by unpleasant words, while left frontal pole was activated only by pleasant words. The results show that activation of the posterior cingulate cortex by emotional stimuli cannot be attributed to the memory-enhancing effects of non-emotional stimulus features. The findings are consistent with the suggestion that this region may mediate interactions of emotional and memory-related processes. The results also extend prior findings that evaluating emotional words consistently activates the subgenual cingulate cortex, and suggest a means of probing this region in patients with mood disorders. (C) 2002 Wiley-Liss, Inc.