Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway
Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway
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DOI：
10.1016/j.bbrc.2018.05.121
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发表时间：
2018-07-07
影响因子：
3.1
通讯作者：
Tian, Ye
中科院分区：
文献类型：
--
作者：
Li, Xin;Wu, Di;Tian, Ye
糖尿病影响心脏结构和功能，导致糖尿病性心肌病。氧化应激产生的活性氧在糖尿病心肌病的发生发展中起重要作用。成纤维细胞生长因子（FGF）19，一种肠因子，被合成并释放到回肠中。在本研究中，我们发现FGF 19通过刺激核红细胞因子2（NE-F2）相关因子2（Nrf 2）的表达以及通过AMPK信号通路减少ROS产生来诱导抗氧化反应。此外，AMPK特异性抑制剂化合物C对AMPK的抑制降低了Nrf 2和血红素加氧酶-1（HO-1）蛋白的表达。综上所述，这些结果表明，FGF 19通过抗氧化防御系统减轻了糖尿病心肌病的发展并恢复了心脏功能。(C)2018由Elsevier Inc.出版
Diabetes affects cardiac structure and function, where it leads to diabetic cardiomyopathy. Reactive oxygen species (ROS) produced by oxidative stress play an important role in the development of diabetic cardiomyopathy. Fibroblast growth factor (FGF) 19, an enterokine, is synthesized and released into the ileum. In the present study, we revealed that FGF19 induced an antioxidant response through stimulating the expression of nuclear erythroid factor 2 (NE-F2)-related factor 2 (Nrf2) and as well as reducing ROS production through the AMPK signaling pathway. Additionally, AMPK inhibition by the AMPK-specific inhibitor compound C decreased Nrf2 and heme oxygenase-1 (HO-1) protein expression. Taken together, these results suggested that FGF19, through the anti-oxidative defense system, attenuated the development of diabetic cardiomyopathy and restored cardiac function. (C) 2018 Published by Elsevier Inc.