Darier's Disease: Treatment With Topical Vitamin A Acid
Darier's Disease: Treatment With Topical Vitamin A Acid
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达里尔氏病：外用维生素 A 酸治疗
DOI：
10.1001/archderm.1968.01610160070015
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发表时间：
1968
影响因子：
--
通讯作者：
A. Kligman
中科院分区：
文献类型：
--
作者：
J. Fulton;P. Gross;C. E. Cornelius;A. Kligman
本文对2例达里尔病进行了局部封闭维生素A酸治疗。经过一段时间的红斑和鳞屑，治疗区域转化为正常外观的皮肤。这种局部缓解持续了几个月。组织学研究显示棘皮溶解和角化不良过程减少。外用维生素A酸是一种药理学刺激物，其作用可能与表皮溶菌酶释放酶有关。
Topical vitamin A acid under occlusion was used on two cases of Darier's disease. After a period of erythema and scaling, the treated areas converted to normal appearing skin. This local remission lasted several months. Histologic studies showed a reduction in the acantholytic and dyskeratotic process. Topical vitamin A acid is a pharmacologic irritant and its action may be related to the release of enzymes from epidermal lysozymes.