Effect of high frequency versus theta-burst repetitive transcranial magnetic stimulation on suicidality in patients with treatment-resistant depression.
Effect of high frequency versus theta-burst repetitive transcranial magnetic stimulation on suicidality in patients with treatment-resistant depression.
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高频重复经颅磁刺激与theta爆发式重复经颅磁刺激对难治性抑郁症患者自杀倾向的影响。
DOI：
10.1111/acps.13412
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发表时间：
2022-05
影响因子：
6.7
通讯作者：
Blumberger, Daniel M.
中科院分区：
文献类型：
--
作者：
Mehta, Shobha;Downar, Jonathan;Mulsant, Benoit H.;Voineskos, Daphne;Daskalakis, Zafiris J.;Weissman, Cory R.;Vila-Rodriguez, Fidel;Blumberger, Daniel M.
关键词：
为了研究10Hz重复经颅磁刺激（rTMS）和间歇性脑波爆发刺激（iTBS）对难治性抑郁症（TRD）患者自杀倾向的影响，我们使用了一项三点随机临床试验的数据，比较了10Hz和iTBS经颅磁刺激对TRD患者左背外侧前额叶皮层（DLPFC）的影响。我们比较了10Hz rTMS和iTBS对汉密尔顿抑郁评定量表第17项（HDRS-17）自杀项目的影响。10Hz刺激组和iTBS组分别有71例（43.7%）和91例（49.1%）自杀倾向得到缓解，两组比例无显著差异（X2 = 0.674, df = 1, p = 0.4117）。两种治疗方式的自杀率变化与抑郁严重程度变化之间存在显著相关性（10Hz, Pearson’s r = 0.564; iTBS, Pearson’s r = 0.502），自杀率缓解者抑郁严重程度的降低明显大于未缓解者（t = 10.912, df = 276.8, p < 0.001）。10Hz和iTBS rTMS均能有效降低TRD患者的自杀率。未来关于iTBS治疗抑郁症的试验应该包括对自杀倾向的离散测量。
To investigate the effect of 10Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) on suicidality in patients with treatment resistant depression (TRD) We used data from a three-site randomized clinical trial comparing 10Hz and iTBS rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in patients with TRD. We compared the effect of 10Hz rTMS and iTBS on suicidality as measured by the suicide item of the Hamilton Depression Rating Scale 17-item (HDRS-17). Suicidality remitted in 71 (43.7%) participants randomized to 10Hz stimulation and 91 (49.1%) participants randomized to iTBS, without a significant difference between the proportions in the two groups (X2 = 0.674, df = 1, p = 0.4117). There was a significant correlation between change in suicidality and change in depression severity for both modalities (10Hz, Pearson’s r = 0.564; iTBS, Pearson’s r = 0.502), with a significantly larger decrease in depression severity for those in whom suicidality remitted compared to those in whom it did not (t = 10.912, df = 276.8, p < 0.001). Both 10Hz and iTBS rTMS were effective in reducing suicidality in TRD. Future trials of iTBS for depression should include discrete measures of suicidality.
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