Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
复制标题
激活诱导的T辅助细胞死亡在鼠类Japonicum感染后导致Th1/Th2极化。
DOI：
10.1155/2010/202397
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发表时间：
2010
影响因子：
--
通讯作者：
Su C
中科院分区：
文献类型：
--
作者：
Xu X;Wen X;Chi Y;He L;Zhou S;Wang X;Zhao J;Liu F;Su C
In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S. japonicum infection, nonegg antigens trigger Th2 cell apoptosis via the granzyme B signal pathway, contributing to Th1 polarization, which is thought to be associated with worm clearance and severe schistosomiasis. Meanwhile, after the adult worms lay their eggs, the egg antigens trigger Th1 cell apoptosis via the caspase pathway, contributing to Th2 polarization, which is associated with mild pathology and enhanced survival of both worms and their hosts. Thus, our study suggests that S. japonicum antigen-induced Th1 and Th2 cell apoptosis involves the Th1/Th2 shift and favorites both hosts and parasites.
