Pattern of alcohol administration and physical dependence.
Pattern of alcohol administration and physical dependence.
复制标题
饮酒模式和身体依赖性。
DOI：
10.1111/j.1530-0277.1983.tb05487.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
G. Aufrère
中科院分区：
文献类型：
--
作者：
B. Le Bourhis;G. Aufrère
本研究的目的是研究饮酒模式对戒断综合征强度的影响。部分大鼠因吸入乙醇蒸气而中毒。在整个实验过程中，空气中的乙醇浓度以这样的方式增加，即在实验期间血液中的乙醇浓度（BAC）作为时间的线性函数增加。当BAC曲线下面积随饮酒时间的变化而变化，BAC增加的斜率不变时，戒断症状的严重程度随饮酒时间的延长而增加。当酒精给药的持续时间和BAC曲线的斜率以BAC曲线下的面积保持恒定的方式变化时，戒断综合征的严重程度随着BAC曲线的斜率而增加。
The purpose of this work was to study the influence of the pattern of alcohol administration on the intensity of withdrawal syndrome. Some rats were intoxicated by inhalation of ethanol vapor. The ethanol concentration in atmosphere was increased throughout the whole experiment in such a manner that the blood alcohol concentration (BAC) during the experiment increased as a linear function of time. When the area under BAC curve was varied by changing the duration of alcohol administration and keeping constant the slope of BAC increase, the intensity of withdrawal syndrome increased with the duration of alcohol intoxication. When the duration of alcohol administration and the slopes of the BAC curves were varied in such a manner that the area under the BAC curves was kept constant, the severity of the withdrawal syndrome increased with the slope of the BAC curves.