The hidden dysfunction of otolithic organs in patients with profound sensorineural hearing loss
The hidden dysfunction of otolithic organs in patients with profound sensorineural hearing loss
复制标题
重度感音神经性聋患者耳石器官的隐性功能障碍
DOI：
10.1016/j.heares.2015.10.006
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发表时间：
2016-01-01
期刊：
影响因子：
2.8
通讯作者：
Chi, Fang-Lu
中科院分区：
文献类型：
--
作者：
Xu, Xin-Da;Ding, Chen-Ru;Chi, Fang-Lu
目的：探讨重度感音神经性听力损失（PSHL）患者眼部和颈部前庭诱发肌源性电位（oVEMP和cVEMP）的变化特征。方法：对29例PSHL患者和20名健康志愿者进行调查。收集并分析患者的医疗记录。测定并分析acs诱发的ovemp、cemp和热量试验。结果：PSHL患者的oVEMP和cemp应答率分别为38.9%和44.4%，显著低于健康志愿者（均为100%）。ovemp的阈值较高（p < 0.001），幅度较小（p = 0.022）。cemps的阈值显著升高（p < 0.001），振幅显著降低（p = 0.024）， P1潜伏期显著降低（p = 0.002）， N1潜伏期显著降低（p = 0.001）。在热量测试方面，PSHL患者半规管功能障碍的比例显著高于健康志愿者（p < 0.001）。然而，在所有29名患者的医疗记录摘要中，患者和医生都没有注意到平衡问题或耳石功能丧失。结论：在ovemp和cemp患者中可以观察到PSHL患者可隐藏的心室和囊性功能障碍。在PSHL的诊断和治疗中应重视耳石功能VEMPs对于观察PSHL患者耳石器官的隐性功能障碍具有特殊的价值。(C) 2015 Elsevier B.V.版权所有
Objective: To define the profiles of ocular and cervical vestibular-evoked myogenic potentials (oVEMP and cVEMP, respectively) in patients with profound sensorineural hearing loss (PSHL).Methods: Twenty-nine patients with PSHL and 20 healthy volunteers were investigated. The patients' medical records were collected and analyzed. The ACS-evoked oVEMPs and cVEMPs and caloric test were tested and analyzed.Results: The oVEMP and cVEMP response rates in the patients with PSHL were 38.9% and 44.4%, respectively, and these values were significantly less than those in the healthy volunteers (both were 100%). Regarding the oVEMPs, significantly higher threshold (p < 0.001) and smaller amplitude (p = 0.022) were observed in the patients. Regarding the cVEMPs, a significant elevation in the threshold (p < 0.001) and a decrease in the amplitude (p = 0.024) were observed, and marked reductions in the P1 (p = 0.002) and N1 latencies (p = 0.001) were observed in the patients. Regarding the caloric test, the ratio of semicircular canal dysfunction in patients with PSHL was significantly higher than that in healthy volunteers (p < 0.001). However, neither the patients nor the doctors noticed balance problems or the loss of otolithic function in the summaries of the medical records of all 29 of the patients.Conclusion: The utricular and saccular dysfunction that can be concealed in patients with PSHL can be observed in oVEMPs and cVEMPs. Otolithic function should receive attention in the diagnosis and treatment of PSHL VEMPs have special value for the observation of hidden dysfunctions of the otolithic organs of patients with PSHL. (C) 2015 Elsevier B.V. All rights reserved.