Percutaneous or intradermal BCG vaccine?
Percutaneous or intradermal BCG vaccine?
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DOI：
10.1590/s0021-75572004000200004
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发表时间：
2004-04-01
影响因子：
3.3
通讯作者：
Bricks, Lucia F.
中科院分区：
文献类型：
--
作者：
Bricks, Lucia F.
目的：比较皮内和经皮途径的BCG administration. SourcesofDATA：1987年和2002年之间发表的文献进行了审查，在MEDLINE和丁香数据库。使用了以下关键词：卡介苗/接种、不良反应、疗效、结核病/预防和控制。1987年之前发表的一些文章被包括在内，因为它们的相关性的topic. Summary的调查结果：有没有临床研究比较皮内和经皮卡介苗的疗效。经皮BCG引起较弱的反应，但它也是不太有效的刺激γ-干扰素生产的Th 1-淋巴细胞，这被认为是最好的标记物的抗结核菌素免疫response.CONCLUSIONS：在体内和体外研究表明，更好的免疫反应与皮内BCG。建议采用皮内注射法接种卡介苗。
OBJECTIVE: To compare the intradermal and percutaneous routes of BCG administration.SOURCES OF DATA: A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/prevention and control. Some articles published before 1987 were included because of their relevance to the topic.SUMMARY OF THE FINDINGS: There are no clinical studies comparing the efficacy of intradermal and percutaneous BCG. Percutaneous BCG causes a weaker reaction, however it is also less efficient in stimulating gamma-interferon production by Th1-lymphocytes, which is considered as the best marker of the anti-tuberculin immune response.CONCLUSIONS: In vivo and in vitro studies suggest a better immune response with intradermal BCG. The intradermal method should be recommended for BCG administration.