Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias.
Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias.
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DOI：
10.1155/2005/218759
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Müller HM
中科院分区：
文献类型：
--
作者：
Goebel G;Zitt M;Zitt M;Müller HM
现在广泛接受的是，需要开发可用于临床诊断和监测的癌症分子标志物。大约十年前，癌症患者血浆或血清中的肿瘤来源的循环核酸（CNAPS）被引入作为癌症检测的非侵入性工具。本文综述了实体瘤患者的各种类型的CNAPS（循环DNA、微卫星、甲基化DNA、病毒DNA、核小体、线粒体DNA和游离mRNA的遗传改变）及其作为预后或预测参数甚至作为随访期间治疗监测工具的推定潜力。此外，本综述旨在指出患者血流中预后和预测因素之间的差异。然而，随着快速的技术进步和精心设计的研究，我们得出结论，未来几年将看到CNAPS分析整合到癌症患者的诊断和监测中，从而为不同阶段的肿瘤疾病患者提供更具体的治疗方案，并最终延长生存期和提高生活质量。
It is now widely accepted that there is a need for the development of molecular markers of cancer that can be used for clinical prognostication and monitoring. Approximately a decade ago tumor-derived circulating nucleic acids in the plasma or serum (CNAPS) of cancer patients were introduced as a noninvasive tool for cancer detection. This review focuses on the various types of CNAPS of patients with solid neoplasias (genetic alterations in circulating DNA, microsatellites, methylated DNA, viral DNA, nucleosomes, mitochondrial DNA and cell-free mRNA) and their putative potential as prognostic or predictive parameter or even as a tool for therapy monitoring during follow-up. Additionally, this review aims to point out the difference between a prognostic and a predictive factor in patient bloodstream. However, with rapid technical improvement and well-designed studies we conclude that the next years will see CNAPS analysis integrated in the prognostication and monitoring of cancer patients, thus producing more specific treatment regimens for patients with various stages of neoplastic disease and ultimately longer survival and better quality of life.
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影响因子：
50.5
作者：
Gonzalez, R;Silva, JM;Bonilla, F
通讯作者：
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影响因子：
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Hoon, DSB
DOI：
10.1073/pnas.101129998
发表时间：
2001-05-22
影响因子：
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