Lesion correlates of auditory sentence comprehension deficits in post-stroke aphasia.
Lesion correlates of auditory sentence comprehension deficits in post-stroke aphasia.
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DOI：
10.1016/j.ynirp.2021.100076
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Mirman D
中科院分区：
文献类型：
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作者：
Adezati E;Thye M;Edmondson-Stait AJ;Szaflarski JP;Mirman D
听觉句子理解需要多个层次的加工协调：听觉-语音知觉、词汇-语义理解、句法分析和语篇构建，以及诸如言语工作记忆和认知控制等执行功能。本研究在以往研究的基础上，采用一种不同的、与临床相关的句子理解测验(Token测验)、多变量测验(SCCAN)和基于连接组的病变-症状映射方法，对卒中后失语患者句子理解缺陷的病变相关性进行了研究。关键的发现是，在单变量和多变量病变-症状图中都可以观察到，颞叶后上回和额下回(三角部)的病变与句子理解障碍有关。在考虑了总的病变大小后，图论测量的连接体中断与句子理解障碍之间没有统计学上的显著相关性。
Auditory sentence comprehension requires coordination of multiple levels of processing: auditory-phonological perception, lexical-semantic comprehension, syntactic parsing and discourse construction, as well as executive functions such as verbal working memory (WM) and cognitive control. This study examined the lesion correlates of sentence comprehension deficits in post-stroke aphasia, building on prior work on this topic by using a different and clinically-relevant measure of sentence comprehension (the Token Test) and multivariate (SCCAN) and connectome-based lesion-symptom mapping methods. The key findings were that lesions in the posterior superior temporal lobe and inferior frontal gyrus (pars triangularis) were associated with sentence comprehension deficits, which was observed in both mass univariate and multivariate lesion-symptom mapping. Graph theoretic measures of connectome disruption were not statistically significantly associated with sentence comprehension deficits after accounting for overall lesion size.