Stage‐dependent and sex‐dependent sensitivity to water‐soluble fractions of fresh and weathered oil in the marine copepod Calanus finmarchicus
Stage‐dependent and sex‐dependent sensitivity to water‐soluble fractions of fresh and weathered oil in the marine copepod Calanus finmarchicus
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海洋桡足类Calanus finmarchicus对新鲜和风化油水溶性成分的阶段依赖性和性别依赖性敏感性
DOI：
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发表时间：
2016
影响因子：
4.1
通讯作者：
B. H. Hansen
中科院分区：
文献类型：
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作者：
T. Jager;D. Altin;Cecilie Miljeteig;B. H. Hansen
急性毒性因物种而异，而且在物种内也有所不同。重要的种内因素是暴露时间和动物的特性，例如生命阶段、性别和生理状态。在本研究中，随着时间的推移，对来自新鲜和人工风化油的水溶性成分（WSF）在桡足类Calanus finmarchicus（包括成年雄性和雌性）的不同生命阶段的急性毒性进行了跟踪。生命阶段的大小不同，脂质含量和生理机能也不同。为了有意义地比较不同阶段的敏感性，作者将通用统一生存阈值模型 (GUTS) 框架中的毒代动力学-毒动力学 (TKTD) 模型与随时间变化的死亡率模式进行了拟合。油WSF不能被视为单一化合物：高剂量下的快速作用与低剂量下的缓慢作用不能协调一致。然而，将石油视为两种成分块的混合物可以令人满意地捕获这些模式。尽管动物的早期生命阶段通常被认为是最脆弱的，但 C. finmarchicus 的成年雄性却是最敏感的，其次是早期桡足类。无节幼体与晚期桡足类和成年雌性一样容易受到油毒性的影响。然而，GUTS 模型参数与不同生命阶段的生理特征之间的关系仍不清楚。环境毒理学化学2016；35：728–735。 © 2015 塞塔克
Acute toxicity differs between species but also varies within a species. Important intraspecific factors are the exposure duration and properties of the animal such as life stage, sex, and physiological status. In the present study, the acute toxicity of water‐soluble fractions (WSFs) from fresh and artificially weathered oil was followed over time in different life stages of the calanoid copepod Calanus finmarchicus, including adult males and females. The life stages differ in size but also in lipid content and physiology. To meaningfully compare the sensitivity of the different stages, the authors fitted a toxicokinetic–toxicodynamic (TKTD) model from the framework of the General Unified Threshold Model of Survival (GUTS) to the mortality patterns over time. The oil WSFs could not be treated as single compounds: the rapid effect at high doses could not be reconciled with the slow effect at low doses. Treating the oil as a mixture of 2 component blocks could, however, capture these patterns satisfactorily. Even though the early life stages of animals are generally considered to be the most vulnerable, the adult males of C. finmarchicus turned out to be most sensitive, followed by the early copepodites. Naupliar larvae were equally susceptible to oil toxicity as late copepodites and adult females. The relationship between the GUTS model parameters and the physiological traits for the different life stages remains, however, unclear. Environ Toxicol Chem 2016;35:728–735. © 2015 SETAC