MicroRNA single-nucleotide polymorphisms and diabetes mellitus: A comprehensive review.
MicroRNA single-nucleotide polymorphisms and diabetes mellitus: A comprehensive review.
复制标题
MicroRNA 单核苷酸多态性和糖尿病：综合综述。
作者：
Zhang Yanfen;Bai Ruocen;Liu Chong;Ma Chunyan;Chen Xin;Yang Jun;Sun D;an
糖尿病（DM）已成为继癌症、心脑血管疾病之后影响全球公共卫生的第三大慢性非传染性疾病。尽管之前的研究已经发现 microRNA (miRNA) 与 DM 发生之间的相关性，但迄今为止，大多数评论都集中在描述 miRNA 表达谱变化以及 miRNA 诱导 DM 机制的研究上。然而，仍需要综述miRNA单核苷酸多态性对DM发展阶段及其并发症的影响。对miRNA变异的研究不仅有助于进一步了解遗传因素在DM中的作用，而且对治疗和疾病预后也具有重要意义。
Diabetes mellitus (DM) has become the third major chronic non‐communicable disease affecting global public health, following cancer and cardiovascular and cerebrovascular diseases. Although previous studies have found a correlation between microRNA (miRNA) and the development of DM, thus far, most reviews have focused on the studies describing the changes in miRNA expression profiles and the mechanisms by which miRNAs‐induce DM. However, reviews summarizing the effect of miRNA single‐nucleotide polymorphisms on the developmental stages of DM and its complications are still needed. Studies on the variation of miRNAs will not only help to further understand the role that genetic factors play in DM, but will also have important implications for treatment and disease prognosis.