Changes in cerebellar fastigial burst activity related to saccadic gain adaptation in the monkey
Changes in cerebellar fastigial burst activity related to saccadic gain adaptation in the monkey
复制标题
DOI：
10.1016/s0168-0102(03)00098-1
复制
发表时间：
2003-07-01
影响因子：
2.9
通讯作者：
Yoshida, K
中科院分区：
文献类型：
--
作者：
Inaba, N;Iwamoto, Y;Yoshida, K
扫视的准确性是由一种可能涉及小脑的自适应机制来保证的。我们研究了在适应过程中眼跳相关神经元在顶眼区（FOR）的放电。采用传统的扫视内步实验范式，将水平10 °目标步引起的扫视增益改变到单位记录的一侧。作为神经活动的测量，我们采取了在扫视开始前30 ms开始的30或40 ms时间窗口中发生的尖峰的数量，其大致对应于爆发的足和上升阶段。增益降低伴随着尖峰放电的显著增加（6/6），增益增加伴随着放电的显著减少（3/3）。在适应过程中，神经元的活动和增益表现出类似的变化过程，但在相反的方向。回归分析表明，两个变量之间存在显著相关（7/8）。目前的研究表明，活动的FOR神经元的改变，在适应性修改扫视的大小。我们的数据是一致的，假设的抑制作用的FOR对同侧扫视，并提供支持，在一个单一的神经元的基础上，小脑参与短期扫视适应。(C)2003年Elsevier Science爱尔兰有限公司和日本神经科学学会。All rights reserved.
The accuracy of saccades is ensured by an adaptive mechanism that probably involves the cerebellum. We examined the discharge of saccade-related neurons in the fastigial oculomotor region (FOR) during adaptation. Using a conventional intrasaccadic step paradigm, we changed the gain of saccades elicited by a 10degrees horizontal target step to the side of unit recording. As a measure of neural activity, we took the number of spikes occurring in a 30 or 40 ms time window starting at 30 ms before saccade onset, which corresponded roughly to the foot and rising phase of the burst. A gain decrease was accompanied by a significant increase in spike discharge (6/6), and a gain increase by a significant reduction in discharge (3/3). During the course of adaptation, the neural activity and gain exhibited changes with a similar course but in the opposite direction. Regression analysis indicated that the two variables were significantly correlated (7/8). The present study has shown that activity of FOR neurons is altered during adaptive modification of saccade size. Our data are consistent with the hypothesized suppressive action of the FOR on ipsiversive saccades and provide support on a single-neuron basis for the cerebellar involvement in short-term saccade adaptation. (C) 2003 Elsevier Science Ireland Ltd and Japan Neuroscience Society. All rights reserved.