Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population
Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population
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DOI：
10.1016/j.envres.2008.01.013
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发表时间：
2008-07-01
影响因子：
8.3
通讯作者：
Patterson, Donald G., Jr.
中科院分区：
文献类型：
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作者：
Li, Zheng;Sandau, Courtney D.;Patterson, Donald G., Jr.
尿中单羟基多环芳烃（OH-PAHs）是一类多环芳烃代谢产物，可作为评估人体暴露于多环芳烃的生物标志物。美国疾病控制和预防中心的全国健康和营养检查调查（NHANES）使用OH-PAH建立美国人口的参考范围浓度，并为未来的流行病学和生物监测研究设定基准。在2001年和2002年，22 OH-PAH代谢物测定尿液标本从2748 NHANES参与者。可检测水平样品的回收率范围从萘、芴、菲和芘代谢物的接近100%到来自较高分子量母体化合物（如苯并[c]菲和苯并[a]蒽）的代谢物的不到5%不等。1-羟基芘（1-PYR）的几何平均值（PAH最常用的生物标志物）为49.6 ng/L尿液或46.4 ng/g肌酐。儿童（6-11岁）的水平一般高于青少年（12-19岁）或成人（20岁及以上）。儿童、青少年（12-19岁）和成人（20岁及以上）1-PYR的模型校正最小二乘几何平均值分别为87、53和43 ng/L。主要可检测的OH-PAHs的对数转换浓度显着相关。1-PYR和其他代谢物之间的相关系数范围为0.17至0.63，支持使用1-PYR作为一个有用的替代代表PAR暴露。(C)2008年爱思唯尔公司All rights reserved.
Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for assessing human exposure to PAHs. The Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey (NHANES) uses OH-PAHs to establish reference range concentrations for the US population, and to set benchmarks for future epidemiologic and biomonitoring studies. For the years 2001 and 2002, 22 OH-PAH metabolites were measured in urine specimens from 2748 NHANES participants. Percentages of samples with detectable levels ranged from nearly 100% for metabolites of naphthalene, fluorene, phenanthrene, and pyrene, to less than 5% for metabolites from parent compounds with higher molecular weight such as chrysene, benzo[c]phenanthrene, and benz[a]anthracene. The geometric mean for 1-hydroxypyrene (1-PYR)-the most commonly used biomarker for PAH exposure-was 49.6 ng/L urine, or 46.4 ng/g creatinine. Children (ages 6-11) generally had higher levels than did adolescents (ages 12-19) or adults (ages 20 and older). Model-adjusted, least-square geometric means for 1-PYR were 87, 53 and 43 ng/L for children, adolescents (ages 12-19) and adults (ages 20 years and older), respectively. Log-transformed concentrations for major detectable OH-PAHs were significantly correlated with each other. The correlation coefficients between 1-PYR and other metabolites ranging from 0.17 to 0.63 support the use of 1-PYR as a useful surrogate representing PAR exposure. (C) 2008 Elsevier Inc. All rights reserved.