Noxious cold evokes multiple sensations with distinct time courses
Noxious cold evokes multiple sensations with distinct time courses
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DOI：
10.1016/s0304-3959(02)00043-x
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发表时间：
2002-07-01
期刊：
影响因子：
7.4
通讯作者：
Pope, GE
中科院分区：
文献类型：
--
作者：
Davis, KD;Pope, GE
一种有害的冷刺激可以引起多种感觉，每种感觉都在不同的时间过程中发生。我们已经进行了心理物理学研究，以确定由施加到手部的有害冷刺激引起的五种感觉的时间过程。受试者从中性（32 ℃）基线开始，在反复呈现有害冷刺激（3 ℃）的过程中，连续评定疼痛、疼痛、冷、热或刺痛感。使用单独的运行来评估五种感觉中的每一种。在整个冷却期间报告了寒冷。疼痛和疼痛感的时间过程相似。然而，刺痛和热感觉有时间，可以彼此区分的过程，以及疼痛和疼痛。这些时间剖面的识别可以提供线索，其潜在的机制。这些感觉的暂时分离也将使与这些感觉相关的皮层机制的神经影像学研究成为可能。因此，我们的研究结果构成了识别与不同类型的疼痛感觉相关的不同神经活动模式的第一步。(C)2002年国际疼痛研究协会。由Elsevier Science B.V.出版，版权所有。
A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensations throughout repeated presentations of a noxious cold stimulus (3degreesC) from a neutral (32degreesC) baseline. Separate runs were used to assess each of the five types of sensation. Cold was reported throughout the period of cooling. The time course of pain and ache sensations were similar. However, prickle and heat sensations had time, courses that could be distinguished from each other, and from ache and pain. Identification of these temporal profiles could provide clues to their underlying mechanisms. The temporal dissociation of these sensations will also enable neuroimaging studies of the cortical mechanisms associated with these sensations. Thus our results constitute a first step toward identifying the distinct modes of neural activity associated with different types of pain sensation. (C) 2002 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.