Mechanisms of myoblast fusion during muscle development.
Mechanisms of myoblast fusion during muscle development.
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DOI：
10.1016/j.gde.2015.03.006
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发表时间：
2015-06
影响因子：
4
通讯作者：
Chen EH
中科院分区：
文献类型：
--
作者：
Kim JH;Jin P;Duan R;Chen EH
骨骼肌的发育和再生需要单核肌细胞融合形成多核、可收缩的肌纤维。利用简单的遗传模型--黑腹果蝇（Drosophila melanogaster）的研究发现了许多进化上保守的体内融合促进因子。最近在斑马鱼和小鼠中的工作还确定了成肌细胞融合所需的几种脊椎动物特异性因子。在这里，我们整合了多个体内系统的进展，并强调了理解肌肉细胞膜如何融合在一起的概念性进展。我们专注于融合突触的分子机制，并提出了一个三步模型来描述导致融合孔形成的分子和细胞事件。
The development and regeneration of skeletal muscles require the fusion of mononulceated muscle cells to form multinucleated, contractile muscle fibers. Studies using a simple genetic model, Drosophila melanogaster, have discovered many evolutionarily conserved fusion-promoting factors in vivo. Recent work in zebrafish and mouse also identified several vertebrate-specific factors required for myoblast fusion. Here, we integrate progress in multiple in vivo systems and highlight conceptual advance in understanding how muscle cell membranes are brought together for fusion. We focus on the molecular machinery at the fusogenic synapse and present a three-step model to describe the molecular and cellular events leading to fusion pore formation.