Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms
Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms
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DOI：
10.1192/bjp.177.5.421
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发表时间：
2000-11-01
影响因子：
10.5
通讯作者：
Davies, EW
中科院分区：
文献类型：
--
作者：
Harrow, M;Grossman, LS;Davies, EW
背景情感性精神障碍的预后与精神分裂症或情感性精神障碍是否更为相似尚不清楚。目的提供关于精神分裂症或情感性精神障碍与精神分裂症和情感性精神障碍的临床病程和预后的纵向数据，并确定情绪不一致的精神病性症状是否具有不良预后意义。方法共210例情感性精神障碍、精神分裂症、精神分裂症和情感性精神障碍患者，双相躁狂症和抑郁症进行了评估，在住院，然后随访四次超过10 years.Results在所有四个后续行动，较少的患者与情感性精神障碍比精神分裂症表现出一致的不良后果。结论分裂情感性精神障碍患者的预后优于精神分裂症患者，但低于精神病性情感障碍患者。情绪不一致的精神病性症状有负面的预后影响。本研究结果符合情绪障碍的症状维度观点。兴趣声明美国国家精神卫生研究所研究基金资助。
Background It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders.Aims To provide longitudinal data on clinical course and outcome in schizophrenia or affective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications.Method A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic-disorders and depression were assessed at hospitalisation and then followed up four times over 10 years.Results At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05).Conclusions Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.Declaration of interest Supported by a research grant from the National institute of Mental Health, USA.