Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging
Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging
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DOI：
10.1007/s00234-012-1044-6
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发表时间：
2012-08-01
期刊：
影响因子：
2.8
通讯作者：
Sluming, Vanessa
中科院分区：
文献类型：
--
作者：
Aldhafeeri, Faten M.;Mackenzie, Ian;Sluming, Vanessa
耳鸣是在没有外界刺激的情况下对声音的一种知之甚少的听觉知觉。一致的证据表明，耳鸣知觉涉及大脑结构的改变，作为其病理生理学的一部分。采用高分辨率磁共振成像和扩散张量成像技术，对14例耳鸣患者和14例年龄、性别匹配的非耳鸣患者的大脑皮质厚度、各向异性分数和平均扩散系数进行了研究。与非耳鸣患者相比，耳鸣患者的前额叶、颞叶和边缘系统的皮质厚度显著减少。耳鸣患者被发现破坏了涉及PFC、颞叶、丘脑和边缘系统连接的束的WM完整性。我们的结果表明，这种神经变化可能是耳鸣的神经起源或耳鸣及其关联的后果。
Tinnitus is a poorly understood auditory perception of sound in the absence of external stimuli. Convergent evidence proposes that tinnitus perception involves brain structural alterations as part of its pathophysiology. The aim of this study is to investigate the structural brain changes that might be associated with tinnitus-related stress and negative emotions.Using high-resolution magnetic resonance imaging and diffusion tensor imaging, we investigated grey matter and white matter (WM) alterations by estimating cortical thickness measures, fractional anisotropy and mean diffusivity in 14 tinnitus subjects and 14 age- and sex-matched non-tinnitus subjects.Significant cortical thickness reductions were found in the prefrontal cortex (PFC), temporal lobe and limbic system in tinnitus subjects compared to non-tinnitus subjects. Tinnitus sufferers were found to have disrupted WM integrity in tracts involving connectivity of the PFC, temporal lobe, thalamus and limbic system.Our results suggest that such neural changes may represent neural origins for tinnitus or consequences of tinnitus and its associations.