The preterm piglet - a model in the study of oesophageal development in preterm neonates.
The preterm piglet - a model in the study of oesophageal development in preterm neonates.
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DOI：
10.1111/j.1651-2227.2009.01564.x
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Lau C
中科院分区：
文献类型：
--
作者：
Rasch S;Sangild PT;Gregersen H;Schmidt M;Omari T;Lau C
Rasch S，Sangild PT，Gregersen H.，施密特M.，Omari T，Lau C.早产仔猪-早产新生儿食管成熟的动物模型。儿科学报......斯德哥尔摩。ISSN ......早产儿很难获得独立的经口喂养。这可能是由于吸吮、吞咽和/或呼吸不足造成的。在阻碍食团转运方面，不成熟的食管动力也可能是一个原因。由于有关早产儿食管运动发育的研究具有侵入性，因此将早产小猪作为潜在的研究模型进行了研究。在出生后第1-2天和第3-4天，通过测压法监测足月仔猪（n=6）和早产仔猪（n=15）的食管动力（EM），持续10 min。仔猪的经口摄食性能和EM与人类相似。足月仔猪很容易完成其喂养，而早产仔猪则没有。它们还表现出更大的蠕动活性和传播速度。在早产仔猪中，蠕动活动随着时间的推移保持不变，但注意到同步运动活动增加和不完全运动活动减少。出现类似坏死性小肠结肠炎（NEC）症状的早产仔猪表现出不典型的食管活动。不成熟的EM可能会导致经口进食困难。NEC样症状可能会对EM产生不利影响。仔猪是研究人类婴儿经口喂养和食管发育的有效研究模型。
Rasch S, Sangild PT, Gregersen H., Schmidt M., Omari T, Lau C. The Preterm Piglet – an Animal Model for the Oesophageal Maturation in Preterm Neonates. Acta Paediatr ...... Stockholm. ISSN ...... Preterm infants have difficulty attaining independent oral feeding. This can ensue from inadequate sucking, swallowing, and/or respiration. In impeding bolus transport, immature oesophageal motility may also be a cause. As studies on the development of oesophageal motility are invasive in preterm infants, the preterm piglet was investigated as a potential research model. Oesophageal motility (EM) of term (n=6) and preterm (n=15) piglets were monitored by manometry for 10 min immediately following bottle feeding on days 1-2 and 3-4 of life. Piglets’ oral feeding performance and EM were similar to those of their human counterparts. Term piglets readily completed their feeding whereas their preterm counterparts did not. They also presented with greater peristaltic activity and propagating velocity. Peristaltic activity remained unchanged over time in preterm piglets, but an increase in synchronous and decrease in incomplete motor activity were noted. Preterm piglets that developed symptoms analogous to necrotizing enterocolitis (NEC) demonstrated uncharacteristic oesophageal activity. Immature EM may cause oral feeding difficulties. NEC-like symptoms may adversely affect EM. The piglet is a valid research model for studying human infant oral feeding and oesophageal development.
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影响因子：
3.8
作者：
Lau, C;Smith, EO;Schanler, RJ
通讯作者：
Schanler, RJ
影响因子：
29.4
作者：
OMARI, TI;MIKI, K;DENT, J
通讯作者：
DENT, J
影响因子：
29.4
作者：
Staiano, Annamaria;Boccia, Gabriella;Clouso, Ray E.
通讯作者：
Clouso, Ray E.
影响因子：
2.6
作者：
SAMEROFF, AJ
通讯作者：
SAMEROFF, AJ
DOI：
10.1097/mpg.0b013e3181752ce7
发表时间：
2009-02-01
影响因子：
2.9
作者：
Jadcherla, Sudarshan R.;Stoner, Erin;Linscheld, Thomas
通讯作者：
Linscheld, Thomas