GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes.
GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes.
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GEneSTATION 1.0：多种进化和功能基因组数据的综合资源，用于研究妊娠相关组织和表型的进化。
DOI：
10.1093/nar/gkv1137
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发表时间：
2016
影响因子：
14.9
通讯作者：
McGary,KristonL
中科院分区：
文献类型：
--
作者：
Kim,Mara;Cooper,BrianA;Venkat,Rohit;Phillips,JulieB;Eidem,HaleyR;Hirbo,Jibril;Nutakki,Sashank;Williams,ScottM;Muglia,LouisJ;Capra,JAnthony;Petren,Kenneth;Abbot,Patrick;Rokas,Antonis;McGary,KristonL
哺乳动物妊娠和怀孕是涉及胎儿、母体和父体基因组相互作用的快速进化过程。GNESTATION数据库（http：//www.example.com）的1.0版整合了哺乳动物的不同类型的组学数据，以促进对妊娠和妊娠相关表型的遗传基础的理解，并加速将模型生物的发现转化为人类。genestation.org GNESTATION使用通用模式生物数据库项目的工具构建，包括生物学感知数据库CHADO，快速数据集成的新工具以及简化合成和用户访问的算法。GNESTATION包含来自23个高质量哺乳动物基因组的妊娠和生殖的精选生活史信息。对于每一个人类基因，GNESTATION包含不同的进化（例如基因年龄、群体遗传学和分子进化统计学）、生物体（例如组织特异性基因和蛋白质表达、差异基因表达、疾病表型）和分子数据类型（例如基因本体论注释，蛋白质相互作用），以及链接到许多一般（例如，PubMed）和妊娠疾病特异性（例如，PTBgene，dbPTB）数据库。通过促进妊娠相关组织和表型中各种功能和进化数据的合成，并实现快速，直观，准确和定制的荟萃分析，GNESTATION为全面研究哺乳动物妊娠的功能和进化提供了一个新的平台。
Mammalian gestation and pregnancy are fast evolving processes that involve the interaction of the fetal, maternal and paternal genomes. Version 1.0 of the GEneSTATION database (http://genestation.org) integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation of discoveries from model organisms to humans. GEneSTATION is built using tools from the Generic Model Organism Database project, including the biology-aware database CHADO, new tools for rapid data integration, and algorithms that streamline synthesis and user access. GEneSTATION contains curated life history information on pregnancy and reproduction from 23 high-quality mammalian genomes. For every human gene, GEneSTATION contains diverse evolutionary (e.g. gene age, population genetic and molecular evolutionary statistics), organismal (e.g. tissue-specific gene and protein expression, differential gene expression, disease phenotype), and molecular data types (e.g. Gene Ontology Annotation, protein interactions), as well as links to many general (e.g. Entrez, PubMed) and pregnancy disease-specific (e.g. PTBgene, dbPTB) databases. By facilitating the synthesis of diverse functional and evolutionary data in pregnancy-associated tissues and phenotypes and enabling their quick, intuitive, accurate and customized meta-analysis, GEneSTATION provides a novel platform for comprehensive investigation of the function and evolution of mammalian pregnancy.