Pathophysiology of celiac disease.
Pathophysiology of celiac disease.
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DOI：
10.1016/j.giec.2012.07.003
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发表时间：
2012-10-01
影响因子：
--
通讯作者：
Jabri, Bana
中科院分区：
文献类型：
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作者：
Kupfer, Sonia S;Jabri, Bana
乳糜泻是遗传、环境和免疫因素相互作用的结果。了解乳糜泻的病理生理学，其中触发因素（小麦，黑麦和大麦）是已知的，无疑将揭示其他自身免疫性疾病（如1型糖尿病）的基本机制，这些疾病具有许多共同的致病性扰动。本综述描述了乳糜泻发病机制的3个领域中的每一个领域的开创性发现，即遗传学，环境触发因素和免疫失调，重点关注新的研究领域，如非HLA遗传变异，肠道微生物组和先天免疫系统的作用。
Celiac disease results from the interplay of genetic, environmental, and immunologic factors. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. This review describes seminal findings in each of the 3 domains of the pathogenesis of celiac disease, namely genetics, environmental triggers, and immune dysregulation, with a focus on newer areas of investigation such as non-HLA genetic variants, the intestinal microbiome, and the role of the innate immune system.