Genome Sequence of a Natural Reassortant H5N2 Avian Influenza Virus from Domestic Mallard Ducks in Eastern China
Genome Sequence of a Natural Reassortant H5N2 Avian Influenza Virus from Domestic Mallard Ducks in Eastern China
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DOI：
10.1128/jvi.02315-12
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Liu, Xiufan
中科院分区：
文献类型：
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作者：
Gu, Min;Huang, Junqing;Liu, Xiufan
在此，我们报道了在血凝素裂解位点具有PLREKRRK-R/GL多基基序的中国重组H5N2禽流感病毒的基因组序列。系统发育分析表明，8个基因均属于欧亚谱系，其中5个基因与H5N1病毒及其H5N5重组后代高度同源。这些数据表明，携带H5N1主干的新型多亚型NA重组可能通过H5N1流行区基因重组产生，这将有助于了解H5亚型禽流感病毒的进化和片段重组机制。
Here, we report the genomic sequence of a Chinese reassortant H5N2 avian influenza virus which possessed the polybasic motif PLREKRRK-R/GL at the hemagglutinin cleavage site. Phylogenetic analysis showed that all eight genes were of the Eurasian lineage, five of which were highly homologous to the endemic clade 2.3.4 H5N1 viruses and their H5N5 reassortant descendants. These data suggested that novel multisubtypic NA reassortants bearing the H5N1 backbone could be generated through genetic reassortment in H5N1 circulating regions, which will help in understanding the evolution and segment reassortment mechanism of H5 subtype avian influenza viruses.