Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus
Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus
复制标题
DOI：
10.1016/j.biomaterials.2015.02.018
复制
发表时间：
2015-05-01
期刊：
影响因子：
14
通讯作者：
Chu, Paul K.
中科院分区：
文献类型：
--
作者：
Lu, Tao;Wen, Jin;Chu, Paul K.
聚醚醚酮（PEEK）具有与骨相似的弹性模量，但仍具有生物惰性和不良的成骨作用。在这项工作中，钽离子注入到PEEK的等离子体浸没离子注入（Pill），在近表面形成Ta 2 O 5纳米粒子。纳米压痕测试结果表明，Ta离子注入PEEK的表面弹性模量更接近于人类皮质骨的表面弹性模量。体外细胞粘附、碱性磷酸酶活性、胶原分泌、细胞外基质矿化和实时PCR分析揭示了大鼠骨髓间充质干细胞（bMSCs）在Ta-PIII改性PEEK上的增强的粘附、增殖和成骨分化。8周后，通过显微CT、连续荧光标记和组织学分析对皮质-松质骨大鼠股骨模型进行体内评价，证实骨整合显著改善。Ta-PIII改性PEEK的骨样弹性模量和改性表面形貌协同诱导bMSCs的成骨分化，并且表面改性材料在牙科和骨科植入物中具有很大的潜力。(C)2015爱思唯尔有限公司版权所有。
Polyetheretherketone (PEEK) possesses a similar elastic modulus as bones but yet suffers from bioinertness and poor osteogenesis. In this work, tantalum ions are implanted energetically into PEEK by plasma immersion ion implantation (Pill) to form Ta2O5 nanoparticles in the near surface. Nano-indentation reveals that the surface elastic modulus of the Ta ion implanted PEEK is closer to that of human cortical bones. In vitro cell adhesion, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization, and real-time PCR analyses disclose enhanced adhesion, proliferation, and osteogenic differentiation of rat bone mesenchymal stem cells (bMSCs) on the Ta-PIII modified PEEK. In vivo evaluation of the cortico-cancellous rat femur model by means of micro-CT, sequential fluorescent labeling, and histological analysis after 8 weeks confirms significantly improved osteointegration. The bone-like elastic modulus and modified surface topography of the Ta-PIII modified PEEK synergistically induce osteogenic differentiation of bMSCs and the surface-modified materials have large potential in dental and orthopedic implants. (C) 2015 Elsevier Ltd. All rights reserved.