The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?
The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?
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DOI：
10.1080/17460441.2021.1850689
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发表时间：
2021-04
影响因子：
6.3
通讯作者：
Rabkin SD
中科院分区：
文献类型：
--
作者：
Zhang S;Rabkin SD
尽管有多种治疗方式和新疗法，但许多癌症和患者并未得到有效治疗。癌症免疫疗法最近取得了突破性进展，但并非对所有癌症类型或患者都有效，并可能产生严重的不良反应。溶瘤病毒（OV）是一种有前途的新的治疗模式，利用病毒生物学和宿主相互作用来治疗癌症。基因工程或天然的OV优先在癌细胞中复制并杀死癌细胞，保留正常细胞/组织，并介导抗肿瘤免疫。本文从历史的角度对OVs作为癌症治疗药物的研究进展进行综述，特别是增强其免疫活性的策略。OV提供了一个多方面的平台，其活动根据亲本病毒和遗传改变进行调节。除了直接的病毒作用之外，许多OV还可以装备有治疗性转基因，以也充当基因治疗载体，和/或与其他药物或疗法组合。OVs是一种非常通用且具有可塑性的癌症治疗方法。它们倾向于靶向细胞和宿主生理学，而不是特定的遗传改变，这可能使广泛的反应。OV的生物学复杂性阻碍了它们的翻译;然而，最近批准的talimogene laherparepvec（T-Vec）已经扩展了该领域。
Despite diverse treatment modalities and novel therapies, many cancers and patients are not effectively treated. Cancer immunotherapy has recently achieved breakthrough status yet is not effective in all cancer types or patients and can generate serious adverse effects. Oncolytic viruses (OVs) are a promising new therapeutic modality that harnesses virus biology and host interactions to treat cancer. OVs, genetically engineered or natural, preferentially replicate in and kill cancer cells, sparing normal cells/tissues, and mediating anti-tumor immunity. This review focuses on OVs as cancer therapeutic agents from a historical perspective, especially strategies to boost their immunotherapeutic activities. OVs offer a multifaceted platform, whose activities are modulated based on the parental virus and genetic alterations. In addition to direct viral effects, many OVs can be armed with therapeutic transgenes to also act as gene therapy vectors, and/or combined with other drugs or therapies. OVs are an amazingly versatile and malleable class of cancer therapies. They tend to target cellular and host physiology as opposed to specific genetic alterations, which potentially enables broad responsiveness. The biological complexity of OVs have hindered their translation; however, the recent approval of talimogene laherparepvec (T-Vec) has invigorated the field.
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影响因子：
5.2
作者：
Baker AT;Aguirre-Hernández C;Halldén G;Parker AL
通讯作者：
Parker AL
影响因子：
3.2
作者：
Burke, Michael J.;Ahern, Charlotte;Weigel, Brenda J.;Poirier, John T.;Rudin, Charles M.;Chen, Yingbei;Cripe, Timothy P.;Bernhardt, M. Brooke;Blaney, Susan M.
通讯作者：
Blaney, Susan M.
DOI：
10.3390/v8100294
发表时间：
2016-10-22
期刊：
Viruses
影响因子：
--
作者：
Aref S;Bailey K;Fielding A
通讯作者：
Fielding A
DOI：
10.1038/nrmicro1927
发表时间：
2008-07
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.9
作者：
Andtbacka, Robert H., I;Collichio, Frances;Kaufman, Howard L.
通讯作者：
Kaufman, Howard L.