Exercise in the postural orthostatic tachycardia syndrome.
Exercise in the postural orthostatic tachycardia syndrome.
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DOI：
10.1016/j.autneu.2014.11.008
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发表时间：
2015-03
影响因子：
2.7
通讯作者：
Levine, Benjamin D.
中科院分区：
文献类型：
--
作者：
Fu, Qi;Levine, Benjamin D.
关键词：
体位性心动过速综合征（POTS）患者有体位不耐受和运动不耐受。与健康久坐者相比，这些患者的峰值摄氧量（VO 2 peak）通常较低，表明身体健康水平较低。在急性运动期间，POTS患者的心率过度增加，每种绝对负荷水平的每搏输出量减少;然而，当以相对负荷（%VO2peak）表示时，患者和健康个体之间的心率反应没有差异。POTS患者和健康人之间的心输出量和VO 2之间的关系相似。短期（即，3个月）的运动训练增加了POTS患者的心脏大小和质量、血容量和VO 2峰值。训练后的运动表现有所改善。具体而言，在训练后的运动期间，与训练前相比，在任何给定的VO 2下，每搏输出量更大，心率更低。峰值心率相同，但峰值每搏输出量和心输出量在训练后更大。训练后，心率从峰值运动中恢复的速度明显更快，表明自主循环控制的改善。提示POTS患者运动时心率调节无内在异常。POTS中的心动过速是由于每搏输出量减少。与运动训练相关的心脏重塑和血容量扩张增加了这些患者的体能并改善了运动表现。
Patients with the Postural Orthostatic Tachycardia Syndrome (POTS) have orthostatic intolerance, as well as exercise intolerance. Peak oxygen uptake (VO2peak) is generally lower in these patients compared with healthy sedentary individuals, suggesting a lower physical fitness level. During acute exercise, POTS patients have an excessive increase in heart rate and reduced stroke volume for each level of absolute workload; however, when expressed at relative workload (%VO2peak), there is no difference in the heart rate response between patients and healthy individuals. The relationship between cardiac output and VO2 is similar between POTS patients and healthy individuals. Short-term (i.e., 3 months) exercise training increases cardiac size and mass, blood volume, and VO2peak in POTS patients. Exercise performance is improved after training. Specifically, stroke volume is greater and heart rate is lower at any given VO2 during exercise after training versus before training. Peak heart rate is the same but peak stroke volume and cardiac output are greater after training. Heart rate recovery from peak exercise is significantly faster after training, indicating an improvement in autonomic circulatory control. These results suggest that patients with POTS have no intrinsic abnormality of heart rate regulation during exercise. The tachycardia in POTS is due to a reduced stroke volume. Cardiac remodeling and blood volume expansion associated with exercise training increase physical fitness and improve exercise performance in these patients.
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影响因子：
2.7
作者：
Carrick-Ranson, Graeme;Hastings, Jeffrey L.;Levine, Benjamin D.
通讯作者：
Levine, Benjamin D.
影响因子：
8.3
作者：
Fu, Qi;VanGundy, Tiffany B.;Levine, Benjamin D.
通讯作者：
Levine, Benjamin D.
影响因子：
5.8
作者：
Galbreath, M. Melyn;Shibata, Shigeki;Levine, Benjamin D.
通讯作者：
Levine, Benjamin D.
影响因子：
37.8
作者：
Chomsky, DB;Lang, CC;Wilson, JR
通讯作者：
Wilson, JR
影响因子：
37.8
作者：
Mancini, D;Katz, S;Aaronson, K
通讯作者：
Aaronson, K