Hepatitis delta infection in Italian patients: towards the end of the story?
Hepatitis delta infection in Italian patients: towards the end of the story?
复制标题
DOI：
10.1007/s15010-016-0956-1
复制
发表时间：
2017-06-01
期刊：
影响因子：
7.5
通讯作者：
Almasio, Piero Luigi
中科院分区：
文献类型：
--
作者：
Stroffolini, Tommaso;Sagnelli, Evangelista;Almasio, Piero Luigi
意大利丁型肝炎病毒感染的流行率在过去几十年中有所下降。旨在评估意大利目前慢性丁型肝炎病毒感染的流行病学，并将目前的研究结果与之前研究的相应数据进行比较。2014年一项涉及分散在全国各地的16个转诊中心的横断面研究。在入组的513名乙型肝炎表面抗原阳性受试者中，61名（11.9%）为抗丁型肝炎阳性，性别比（M/F）为2.05。其中大多数（80.3%）年龄在50岁以上，而30岁以下的受试者比例低至3.3%。居住地理区域没有发现差异。 52.4%的病例被诊断出患有肝硬化。与之前的研究相比，观察到抗δ病毒阳性受试者进一步向高龄组转移，肝硬化受试者比例增加。目前，δ型肝炎感染主要影响患有晚期但惰性肝病的老年人，反映了生存效应。有缺陷的丁型肝炎病毒在该国已接近消失，该病毒于 70 年代后半叶被发现。
The endemicity of hepatitis delta virus infection in Italy has decreased in the last decades.To evaluate the current epidemiology of chronic delta infection in Italy and to compare the present findings with the corresponding figures from the previous studies.A cross-sectional study involving 16 referral centres scattered all over the country in 2014.Out of the 513 hepatitis B surface antigen-positive subjects enrolled, 61 (11.9%) were anti-delta positive, with a sex ratio (M/F) of 2.05. The majority (80.3%) of them was 50 years or older, while the proportion of subjects younger than 30 years of age was as low as 3.3%. No difference was detected by geographical area of residence. The presence of liver cirrhosis was diagnosed in 52.4% of cases. In comparison to previous studies, a further shift towards the oldest age groups and an increasing proportion of subjects having liver cirrhosis among all anti-delta-positive subjects are observed.Currently, hepatitis delta infection mostly affects old people who have an advanced but indolent liver disease, reflecting a survival effect. The defective hepatitis delta virus is near to disappear in the country, where it has been discovered in the second half of 70s.