Safety of influenza vaccination during pregnancy
Safety of influenza vaccination during pregnancy
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DOI：
10.1016/j.ajog.2004.12.019
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发表时间：
2005-04-01
影响因子：
9.8
通讯作者：
Glezen, WP
中科院分区：
文献类型：
--
作者：
Munoz, FM;Greisinger, AJ;Glezen, WP
目的：本研究的目的是评估流感疫苗的安全性，是在第二或第三季度的管理gestation.Study设计：一个回顾性的电子数据库搜索5流感季节（1998年7月1日至2003年6月30日）进行了在休斯敦，得克萨斯州的一个大型多专科诊所。免疫接种率进行了计算，妊娠结局进行了比较队列的健康妇女谁收到流感疫苗和对照组的健康未接种疫苗的妇女谁是匹配的年龄，分娩月，和类型的医疗保险。结果：在7183符合条件的母婴对，只有252名孕妇（3.5%）收到流感疫苗。有医疗保险的妇女更有可能接种疫苗，尽管无论保险状况如何，患有慢性基础疾病的妇女的接种率与健康妇女相似。接种流感疫苗时的平均胎龄为26.1周（范围：14-39周）。接种后42天内未发生严重不良事件，两组孕妇妊娠结局（包括剖宫产和早产）和婴儿出生至6月龄的医疗状况无差异。结论：妊娠中期或晚期接种流感疫苗对本研究人群是安全的。(c)2005年爱思唯尔公司All rights reserved.
Objective: The purpose of this study was to evaluate the safety of influenza vaccine that is administered in the second or third trimester of gestation.Study design: A retrospective electronic database search of 5 influenza seasons (July 1, 1998, to June 30, 2003) was performed at a large multispecialty clinic in Houston, Texas. Immunization rates were calculated, and outcomes of pregnancy were compared between a cohort of healthy women who received influenza vaccine and a control group of healthy unvaccinated women who were matched by age, month of delivery, and type of medical insurance.Results: Among 7183 eligible mother-infant pairs, only 252 pregnant women (3.5%) received the influenza vaccine. Women with medical insurance were more likely to be vaccinated, although the rates for women with chronic underlying conditions were similar to those of healthy women, regardless of insurance status. The mean gestational age at the time of influenza vaccination was 26.1 weeks (range, 14-39 weeks). No serious adverse events occurred within 42 days of vaccination, and there was no difference between the groups in the outcomes of pregnancy (including cesarean delivery and premature delivery) and infant medical conditions from birth to 6 months of age.Conclusion: Influenza vaccine that was administered in the second or third trimester of gestation was safe in this study population. (c) 2005 Elsevier Inc. All rights reserved.