he histamine H1 receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.
he histamine H1 receptor antagonist hydroxyzine enhances sevoflurane and propofol anesthesia: A quantitative EEG study.
复制标题
组胺 H1 受体拮抗剂羟嗪增强七氟烷和丙泊酚麻醉：一项定量脑电图研究。
DOI：
10.1016/j.clinph.2021.05.024
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发表时间：
2021
影响因子：
4.7
通讯作者：
Kawamata M
中科院分区：
文献类型：
--
作者：
Tanaka R;Tanaka S;Hayashi K;Iida K;Sawa T;Kawamata M
目的本研究的目的是确定羟嗪对七氟醚麻醉和丙泊酚麻醉期间脑电图的麻醉促进作用。方法我们分析了 40 例在七氟醚麻醉（n = 20）或异丙酚麻醉（n = 20）下计划进行择期手术的患者。调整麻醉至脑电双频指数值50~60，然后静脉注射羟嗪0.5mg/kg。我们通过功率谱和双相干分析对注射羟嗪前后的额叶脑电图进行了分析，这些分析适用于评估 γ-氨基丁酸 (GABA) 能麻醉剂诱导的麻醉深度。结果羟嗪增加了两种七氟醚麻醉中的 α 双相干峰（平均差为 11.2%；95% 置信区间 (CI)，7.6）至 14.8；P<0.001）和异丙酚麻醉（平均差，5.6%；95% CI，1.7 至 9.4；P=0.008）。羟嗪增加了七氟醚麻醉（平均差异，5.5%；95% CI，2.1 至 8.8；P=0.003）和异丙酚麻醉（平均差异，3.9%；95% CI，1.0 至 6.8；P=0.011）的平均 δ 双相干值。七氟烷麻醉和异丙酚麻醉可能是通过促进 GABA 神经回路机制实现的。意义：这些发现为人类全身麻醉过程中组胺能神经元的作用提供了新的见解。
ObjectiveThe aim of this study was to determine the anesthesia-promoting effects of hydroxyzine on electroencephalograms during sevoflurane anesthesia and during propofol anesthesia.MethodsWe analyzed 40 patients scheduled for elective surgery under sevoflurane anesthesia (n = 20) or propofol anesthesia (n = 20). Anesthesia was adjusted at a bispectral index value of 50–60, and then 0.5 mg/kg of hydroxyzine was administered intravenously. We analyzed frontal electroencephalograms before and after hydroxyzine injection with power spectral and bicoherence analyses, which are suitable for assessing the anesthetic depth induced by γ-aminobutyric acid (GABA)ergic anesthetics.ResultsHydroxyzine increased the α bicoherence peaks in both sevoflurane anesthesia (mean difference, 11.2%; 95% confidence interval (CI), 7.6 to 14.8;P< 0.001) and propofol anesthesia (mean difference, 5.6%; 95% CI, 1.7 to 9.4;P= 0.008). Hydroxyzine increased the averaged δ bicoherence values in both sevoflurane anesthesia (mean difference, 5.5%; 95% CI, 2.1 to 8.8;P= 0.003) and propofol anesthesia (mean difference, 3.9%; 95% CI, 1.0 to 6.8;P= 0.011).ConclusionsHydroxyzine enhances both sevoflurane anesthesia and propofol anesthesia probably by facilitation of GABAergic neural circuit mechanisms.SignificanceThe findings provide a new insight into the role of histaminergic neurons during general anesthesia in humans.