Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.
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DOI：
10.1084/jem.179.5.1409
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发表时间：
1994-05-01
期刊：
影响因子：
--
通讯作者：
Strieter RM
中科院分区：
文献类型：
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作者：
Smith DR;Polverini PJ;Kunkel SL;Orringer MB;Whyte RI;Burdick MD;Wilke CA;Strieter RM
我们研究了白细胞介素8（IL-8）在人支气管肺癌中介导血管生成的作用。与正常肺组织相比，肿瘤组织中检测到IL-8的量增加。肿瘤的免疫组织化学染色显示IL-8主要定位于单个肿瘤细胞，并证明了肿瘤产生IL-8的能力。使用肿瘤组织匀浆的功能研究表明，在体外内皮细胞趋化性和体内角膜新生血管的诱导。重要的是要注意，向这些测定中加入IL-8的中和抗血清导致这些应答的显著和特异性减弱。我们的观察明确确立了IL-8作为支气管肺癌血管生成的主要介质，并为实体恶性肿瘤的免疫治疗提供了潜在的靶点。
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies.