SYNERGISTIC RESPONSES AND RECEPTOR OCCUPANCY IN RABBIT-BLOOD PLATELETS
SYNERGISTIC RESPONSES AND RECEPTOR OCCUPANCY IN RABBIT-BLOOD PLATELETS
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DOI：
10.1016/0049-3848(82)90061-5
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发表时间：
1982-01-01
影响因子：
7.5
通讯作者：
WALLIS, RB
中科院分区：
文献类型：
--
作者：
HALLAM, TJ;SCRUTTON, MC;WALLIS, RB
同时受体占有显然是必要的产生的协同反应，兔血小板2兴奋性激动剂。首先，预先加入5-HT [5-羟色胺]诱导的对肾上腺素[肾上腺素]的聚集反应迅速逆转，除非通过抑制5-HT摄取而稳定。反应的程度与细胞外5 HT浓度相关。第二，如果对这种激动剂的反应是由先前加入ADP诱导的，那么在肾上腺素之后加入ADP可以提高解聚率。第三，如果在诱导的聚集反应完成后加入对诱导激动剂有选择性的拮抗剂，则诱导或增强解聚。机制的显著不稳定性显然是产生协同反应的原因。
Simultaneous receptor occupancy apparently is necessary for generation of a synergistic response of rabbit platelets to 2 excitatory agonists. First, an aggregatory response to adrenaline [epinephrine] induced by prior addition of 5HT [5-hydroxytryptamine] reverses rapidly unless stabilized by inhibition of 5HT uptake. The extent of response correlates with the extracellular 5HT concentration. Second, addition of an ADPase following adrenaline enhances the rate of disaggregation if the response to this agonist was induced by prior addition of ADP. Third, disaggregation is induced, or enhanced, if an antagonist selective to the inducing agonist is added following completion of the induced aggregatory response. Marked lability in the mechanisms is apparently responsible for generation of synergistic responses.