Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system
Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system
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DOI：
10.1088/0031-9155/57/2/n1
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发表时间：
2012-01-21
影响因子：
3.5
通讯作者：
Hatazawa, Jun
中科院分区：
文献类型：
--
作者：
Yamamoto, Seiichi;Watabe, Tadashi;Hatazawa, Jun
硅光电倍增管（Si-PM）具有高增益和对静磁场不敏感的特点，是一种很有前途的磁共振成像（MRI）PET光电探测器。最近，我们开发了一种基于Si-PM的小动物相互作用深度PET系统，并通过将基于Si-PM的PET与0.15 T永久MRI相结合来进行同步测量，以测试基于Si-PM的PET与MRI之间的干扰。当Si-PM位于MRI内部并安装在MRI的射频（RF）线圈周围时，在PET探测器的模拟信号中观察到来自MRI RF序列的显著噪声。然而，我们在PET图像中没有观察到任何伪影;基于Si-PM的PET系统的计数率波动增加。在MRI侧，与未使用PET的MRI图像相比，MRI图像的信噪比（S/N）显著降低。通过应用降噪程序，降低了S/N的退化。在这种条件下，使用基于Si-PM的PET和MRI同时测量大鼠大脑，MRI图像中存在一些退化。我们的结论是，同时测量是可能的，使用硅-PM为基础的PET和MRI。
The silicon photomultiplier (Si-PM) is a promising photo-detector for PET for use in magnetic resonance imaging (MRI) systems because it has high gain and is insensitive to static magnetic fields. Recently we developed a Si-PM-based depth-of-interaction PET system for small animals and performed simultaneous measurements by combining the Si-PM-based PET and the 0.15 T permanent MRI to test the interferences between the Si-PM-based PET and an MRI. When the Si-PM was inside the MRI and installed around the radio frequency (RF) coil of the MRI, significant noise from the RF sequence of the MRI was observed in the analog signals of the PET detectors. However, we did not observe any artifacts in the PET images; fluctuation increased in the count rate of the Si-PM-based PET system. On the MRI side, there was significant degradation of the signal-to-noise ratio (S/N) in the MRI images compared with those without PET. By applying noise reduction procedures, the degradation of the S/N was reduced. With this condition, simultaneous measurements of a rat brain using a Si-PM-based PET and an MRI were made with some degradation in the MRI images. We conclude that simultaneous measurements are possible using Si-PM-based PET and MRI.