Neural mechanisms of smooth pursuit eye movements in schizotypy
Neural mechanisms of smooth pursuit eye movements in schizotypy
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DOI：
10.1002/hbm.22632
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发表时间：
2015-01
影响因子：
4.8
通讯作者：
I. Meyhöfer;M. Steffens;A. Kasparbauer;P. Grant;B. Weber;U. Ettinger
中科院分区：
文献类型：
--
作者：
I. Meyhöfer;M. Steffens;A. Kasparbauer;P. Grant;B. Weber;U. Ettinger
精神分裂症患者以及高水平分裂型个体都有平滑追求眼动（SPEM）缺陷。在这里，我们首次研究了高分裂型患者SPEM表现的神经机制。31名健康参与者[N = 19名低分裂型，N = 12名高分裂型（HS）]在3T时接受了功能磁共振成像和并发眼部记录，同时在两个速度（0.2和0.4 Hz）的正弦刺激下执行SPEM任务。在行为上，分裂型组与速度组在SPEM期间的扫视频率存在显著的相互作用，表明在慢速条件下HS受损，而在快速条件下HS受损。在神经水平上，HS在枕叶不同区域（V3A、枕中回和梭状回）表现出较低的大脑激活，这些区域已知与早期感觉和注意加工以及运动感知相关。这组神经激活的差异与靶速度无关。总之，这些发现重复了对高度分裂型个体追求表现改变的观察，并首次确定了伴随这些表现变化的大脑激活模式。这些后激活差异与精神分裂症文献中运动加工缺陷的证据相一致，因此表明精神分裂症和精神分裂症在认知知觉和神经生理水平上存在重叠。然而，精神分裂症患者在追求过程中观察到的额叶运动区域的缺陷在这里没有发现，这表明在临床疾病中存在额外的遗传和/或疾病相关的影响。中国生物医学工程学报，36(3):334 - 353,2015。©2014 Wiley期刊公司
Patients with schizophrenia as well as individuals with high levels of schizotypy are known to have deficits in smooth pursuit eye movements (SPEM). Here, we investigated, for the first time, the neural mechanisms underlying SPEM performance in high schizotypy. Thirty‐one healthy participants [N = 19 low schizotypes, N = 12 high schizotypes (HS)] underwent functional magnetic resonance imaging at 3T with concurrent oculographic recording while performing a SPEM task with sinusoidal stimuli at two velocities (0.2 and 0.4 Hz). Behaviorally, a significant interaction between schizotypy group and velocity was found for frequency of saccades during SPEM, indicating impairments in HS in the slow but not the fast condition. On the neural level, HS demonstrated lower brain activation in different regions of the occipital lobe known to be associated with early sensory and attentional processing and motion perception (V3A, middle occipital gyrus, and fusiform gyrus). This group difference in neural activation was independent of target velocity. Together, these findings replicate the observation of altered pursuit performance in highly schizotypal individuals and, for the first time, identify brain activation patterns accompanying these performance changes. These posterior activation differences are compatible with evidence of motion processing deficits from the schizophrenia literature and, therefore, suggest overlap between schizotypy and schizophrenia both on cognitive‐perceptual and neurophysiological levels. However, deficits in frontal motor areas observed during pursuit in schizophrenia were not seen here, suggesting the operation of additional genetic and/or illness‐related influences in the clinical disorder. Hum Brain Mapp, 36:340–353, 2015. © 2014 Wiley Periodicals, Inc.