Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?
Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?
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DOI：
10.1097/nan.0000000000000103
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Intaglietta M
中科院分区：
文献类型：
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作者：
Tsai AG;Vázquez BY;Hofmann A;Acharya SA;Intaglietta M
深度贫血时的供氧能力取决于血液的携氧能力和心输出量。携带氧气的血液替代品和输血增加了携带氧气的能力，但两者都引起了安全问题，其有效性仍未得到解决。贫血会降低携氧能力和血液粘度。目前的研究表明，新开发的血浆扩张器通过增加血浆粘度来纠正血液粘度的下降，可以显著改善组织灌注。这些新的血浆扩张剂促进组织灌注，在不增加血液携氧能力的情况下增加氧输送能力，从而在避免输血的同时治疗贫血的影响。
Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.