The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling.
The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling.
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骨源性外泌体和外泌体 microRNA 在调节骨重塑中的作用
DOI：
10.1111/jcmm.13039
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发表时间：
2017-05
影响因子：
5.3
通讯作者：
Tang P
中科院分区：
文献类型：
--
作者：
Xie Y;Chen Y;Zhang L;Ge W;Tang P
病理性的破坏性骨病主要是由骨骼系统的终生自我更新过程失败引起的，这种过程称为骨重塑。这一过程背后的机制包括增强破骨细胞活性和减少成骨细胞谱系的生成。这些细胞类型之间的细胞间相互作用和串扰对于维持骨重建至关重要，无论是通过分泌生长因子还是直接细胞-细胞物理接触。最近的研究表明，来源于骨细胞的外体，包括破骨细胞、成骨细胞及其前体，通过将生物活性分子转移到靶细胞，特别是在破骨细胞和成骨细胞分化的过程中，在骨重建中发挥关键作用。在此，我们对骨源性外切体的含量及其在破骨细胞和成骨细胞分化和通讯调节过程中的功能进行综述。此外，我们还重点介绍了参与骨重塑调控的骨源性外切体的microRNAs的特点，以及骨源性外切体在骨重塑疾病中的潜在临床应用。
Pathological destructive bone diseases are primarily caused by the failure of a lifelong self‐renewal process of the skeletal system called bone remodelling. The mechanisms underlying this process include enhanced osteoclast activity and decreased generation of the osteoblast lineage. Intercellular interaction and crosstalk among these cell types are crucial for the maintenance of bone remodelling, either through the secretion of growth factors or direct cell–cell physical engagement. Recent studies have revealed that exosomes derived from bone cells, including osteoclasts, osteoblasts and their precursors, play pivotal roles on bone remodelling by transferring biologically active molecules to target cells, especially in the processes of osteoclast and osteoblast differentiation. Here, we review the contents of bone‐derived exosomes and their functions in the regulatory processes of differentiation and communication of osteoclasts and osteoblasts. In addition, we highlight the characteristics of microRNAs of bone‐derived exosomes involved in the regulation of bone remodelling, as well as the potential clinical applications of bone‐derived exosomes in bone remodelling disorders.